Acryl-EZE® Aqueous Acrylic Enteric System
Acryl-EZE®, aqueous enteric systems are a range of fully formulated, high performance coatings that provide pH targeted resistance. The formulations are designed for use on tablets or multiparticulate solid oral dosage products, including proton pump inhibitor (PPI) applications.
Targeted pH Applications
Acryl-EZE is convenient for use, presenting significant time savings in development and production, and protects against acidic conditions and fast release in buffer (small intestinal fluids) conditions.. Available for use with choice of plasticizer for application flexibility and customization.
Acryl-EZE II is an optimized high performance coating that offers enteric protection in the intermediate pH range media, suitable for proton pump inhibitor (PPI) applications and provides enteric protection at lower weight gains compared to Acryl-EZE systems.
Product LiteratureGeneral Information Product Process Parameters Product Recon Sheet Product Brochure Published Posters
Product Process Parameters
Product Recon Sheet
AAPS 2005 - New Coating Process for the Application of Enteric Coatings to Small Tablet SamplesView and Download Send by Email
Investigation of a rapid application of an aqueous enteric coating system onto very small batch sizes of tablets using a novel coating process technology, the SUPERCELL™ process from Niro.
AAPS 2005 - The Influence of Gastric Media (In-Vitro) on the Performance of Delayed Release Proton Pump Inhibitor Dosage FormsView and Download Send by Email
Invstigation of the enteric performance of aqueous enteric-coated tablet formulations containing proton pump inhibitors (PPI’s) in bio-relevant media, better simulating the gastric environment of a patient on a multiple dose regimen of PPI’s.
AAPS 2008 - Evaluation of the Enteric Performance of Lansoprazole Mini-Tabs Coated in a Perforated PanView and Download Send by Email
The focus of this study was to investigate the potential of successful manufacture and enteric coating of lansoprazole mini-tabs using methacrylic acid co-polymers in a perforated pan. Along with other findings, this study will show that the mechanical strength of the mini-tabs significantly improved upon application of a seal-coat.
AAPS 2010 - Effects of Core Tablet Size on the Functionality of Aqueous Delayed Release Coatings as Measured by SEM and LIBSView and Download Send by Email
The aim of this work was to develop a correlation between tablet surface area (size) and the minimum amount of coating weight gain/thickness of a functional coating necessary for enteric protection of tablets. The film coat thickness was determined via scanning electron microscopy (SEM) and laser-induced breakdown spectroscopy (LIBS).Acryl-EZE 93O formulations
CRS 2003 - Preparation of Stable, Gastro-Resistant Diclofenac Sodium Tablets, Utilizing Optimized Film-Coating CombinationsView and Download Send by Email
Demonstration of how to reduce overall coating process time and achieve drug product stability, by incorporating pigments directly into the Acryl-EZE enteric film layer.
CRS 2007 - The Influence of Plasticizer Type and Concentration on Acid Resistance of Coated TabletsView and Download Send by Email
Investigation of the influence of plasticizer type and concentration on acid resistance, when added to Acryl-EZE® 93A, aqueous delayed-release (DR) film coating systems.
CRS 2008 - Investigation of Enteric Coating of Min-tabs Using a Perforated Pan or a Fluid-bed MachineView and Download Send by Email
Feasibility study of using a perforated coating pan evaluated and compared to a fluid-bed machine. Differences between the two processes, in terms of coated tablet appearance, physical properties and enteric protection were studied.
CRS 2010 - A Comparison of Delayed Release Film Coating Systems for Pharmaceutical Dosage FormsView and Download Send by Email
This study compares the dispersion properties, film properties and enteric performance at varying pH conditions, of four commercially available aqueous,delayed release film coating systems.
Save Time in Development and Production
- Fully formulated, complete system
- Simple to dispense and disperse (20 minutes), with easy clean up
- Reduced raw material inventory and QC requirements
- Suitable for use on tablets, granules, multiparticulates
- Performance validated through in vivo studies
Colorcon can help to reduce your project time by providing the right solution through excipient selection and process guidance.
Lower total cost and reduce time to market
Life cycle management through modified delivery profiles and product line extensions
Reduce medication errors and improve patient adherence
Stable and consistent product performance
Track and trace