SUGLETS® Sugar Spheres
For All Round Consistency and Robustness
Your choice for drug layering applications
Multiparticulate drug delivery systems are increasing as pharmaceutical companies seek to improve clinical effectiveness. Sugar spheres, as a starting substrate, provide a reliable platform for drug loading.
SUGLETS from Colorcon are uniform drug layering pellets, made of sucrose and starch, for sustained or extended release dosage forms. With low friability, consistent sphericity, tight particle size control and high batch-to-batch uniformity, Suglets are ideal for drug loading applications.
The selection of the right sugar sphere is a crucial part of the formulation, so it’s important to understand the critical success factors for drug loading:
- Surface roughness and sphericity to ensure uniform application
- Reliable and reproducible uniformity for batch-to-batch consistency
- Range of particle sizes to meet different dose levels
- Low friability and hardness to withstand the rigors of processing
- Available in a range of sizes
Suglets specifications comply with the current version of the USP/NF and PhEur, and are in compliance with applicable excipient GMP requirements.
With two manufacturing sites, both ISO9001 compliant and dedicated to pharmaceutical production of sugar spheres, you can be confident that Suglets meet the premium quality expected from a highly reputable supplier of pharmaceutical excipients. Studies demonstrate the interchangeability of quality and performance and continuous supply is secured with the two interchangeable manufacturing sites. A robust Business Continuity Plan is in place.
Contact Colorcon to find out why SUGLETS should be your first choice for consistent quality!
- AAPS 2004 - Comparative Study of Theoretical Versus Actual Weight Gain for a Surelease® Barrier Membrane on Coated Pellets
- AAPS 2007 - Hydro-Alcoholic Applications of Polyvinyl Acetate Phthalate (PVAP) for Oral Delayed Release Coating Systems
- AAPS 2007 - Identification and Influence of Critical Coating Process Parameters on Drug Release from a Fully Formulated Aqueous Ethylcellulose Dispersion
- AAPS 2007 - Influence of Hydrophilic Pore-Formers on Dipyridamole Release from Aqueous Ethylcellulose Film-Coated Pellets
- AAPS 2008 - Influence of Post Coating Thermal Treatment on Film Properties and Drug Release from Ethylcellulose Barrier Membrane Coating Systems
- AAPS 2014 - A QbD Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate Extended Release Multiparticulates
- AAPS 2014 - Evaluation of a Process Relevant Method for Determining the Robustness of a Sugar Sphere Drug Layering Substrate
- AAPS 2015 - Effect of Coating Weight Gain and Pore-Former Level on Drug Release with a Fully Formulated Ethylcellulose Barrier Membrane Coating System
- AAPS 2015 - Feasibility of Taste-Masking a Highly Soluble Drug via Powder Layering with Fine Particle Ethylcellulose
- AAPS 2016 - Effect of Surelease® Coating Conditions and Seal-coat on a Highly Soluble, Cationic Drug
- AAPS 2016 Optimization of Extrusion Spheronization Process for Multiparticulates via Design of Experiments
- CRS 2005 - Predictability of Drug Release from Multiparticulate Systems Coated with an Aqueous Ethylcellulose Dispersion
- CRS 2007 - Application of an Aqueous Ethylcellulose Dispersion in Multiple-Unit Pellet Systems
- CRS 2007 - Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Non-Pareil Beads
- CRS 2007 - Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose Coating
- CRS 2008 - Influence of Solvent Type on ER Coating with Ethylcellulose Barrier Membranes
- CRS 2008 - Investigation of Venlafaxine HCl Release from Extruded and Spheronized Beads Coated with Ethylcellulose using Organic or Aqueous Coating Systems
- CRS 2009 - Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated Multiparticulates
- CRS 2009 - Influence of Molecular Weight on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
- CRS 2009 - Influence of Plasticizer Type and Level on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
- CRS 2010 - Influence of Pore-Former on Drug Release from Ethylcellulose Coated Multiparticulates
- CRS 2010 - Stability of a Sparingly Soluble BCS Class I API Ethylcellulose Coated Multiparticulate
- CRS 2011 - Influence of Dissolution Media pH on Drug Release from Ethylcellulose Coated Multiparticulates
- CRS 2011 - Influence of Drug Solubility on Release from Ethylcellulose Barrier Membrane Coated Multiparticulates
- CRS 2016 - Compositional and Performance Stability of a Fully Formulated Ethylcellulose
- CRS 2016 - Study of Dose-Weight Proportionality in Extended Release Multiparticulate Systems Different
- CRS 2016 - Why Choose Small Sugar Spheres