Starch 1500® Partially Pregelatinized Maize Starch
Starch 1500 is a proven and trusted unique pharmaceutical excipient, manufactured exclusively for the global pharmaceutical industry.
- Stabilizes moisture sensitive drugs
- Provides excellent low dose content uniformity
- Meets regulatory standards
Starch 1500 is particularly effective with moisture sensitive actives and low dose applications. In addition to providing a unique range of functions and flexible performance in a variety of applications, Starch 1500 cuts process and material costs by reducing or eliminating binders, superdisintegrants, high levels of lubricants and glidants.
Product LiteratureProduct Application Data General Information Product Brochure Published Posters Published White Papers / Articles
Product Application Data
Assessment of Low Dose Content Uniformity of IndomethacinView and Download
Comparison of excipients and content uniformity in a formula containing a very low dose of indomethacin
Direct Compression Formulation of Loratadine (10 mg) TabletsView and Download
Starch 1500 in a lactose free, low dose active formulation, loratadine
Increasing the Compactability of Echinacea Purpurea Powder using Starch 1500®View and Download
Treating a high dose, poorly compressible herbal powder with Starch 1500 and fumed silica to increase compressibility
Lactose Replacement with Starch 1500® in a direct compression formulaView and Download
Robust, more stable placebo tablet via DC compared to a similar lactose based formulation
Replacement of Di Basic Calcium Phosphate with Starch 1500® in a DC FormulaView and Download
Benefits of using Starch 1500 in a DC placebo formulation replacing DCP
Starch 1500® as a Binder and Disintegrant in XCH (Xiaochaihu) Herbal Extract/Powder TabletView and Download
High dose tablet formulation of XCH herbal extract/powder combination using Starch 1500/MCC in a high-shear granulation process
Starch 1500® used as a Binder Disintegrant in High Shear Wet Granulation Comparison to Povidone and Croscarmellose SodiumView and Download
Starch 1500 reduces overall cost and complexity of a formulation, in comparison to povidone and croscarmellose sodium
Wet Granulation of Acetaminophen with Starch 1500®View and Download
Improvement in tablet hardness and disintegration of Starch 1500 vs PVP
Free and Bound Water in Starch 1500® compared to other excipientsView and Download
Comparison of Water Activity vs LOD of commonly used excipients.
Improving the Stability of a Moisture-Sensitive Drug - Ranitidine HClView and Download
Insights on Moisture Scavenging Properties of Starch 1500®View and Download
Technical Bulletin: Starch 1500®View and Download
Typical properties and key applications for Starch 1500 in oral solid dose formulation
AAPS 2005 - Particle Swelling and Coalescence to Gel Layer FormationView and Download
Swelling and coalescence behavior of HPMC and Starch 1500, in order to monitor the contribution to gel layer formation in matrices.
AAPS 2006 - Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst EffectView and Download
Method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL matrices.
AAPS 2008 - Narrowing the Gap Between Clinical and Commercial FormulationsView and Download
Developing a single formula that can be encapsulated into hard gelatin capsules for clinical studies and compressed into tablets for commercialization.
AAPS 2010 - Effect of Filler Type on Low Dose Acetaminophen Hydrophilic Matrix FormulationsView and Download
Effect of four commonly used fillers in formulation and processing of HPMC matrices utilizing a high shear wet granulation process.
AAPS 2010 - Influence of Filler Type in the Blend Uniformity of Micronized DrugsView and Download
Choice of filler for a low-dose micronized drug to assist dispersibility and uniformity of the drug
AAPS 2011 - Barrier Membrane Coating of Hydrophilic Matrices of Sparingly Soluble Drug, Acetaminophen: A Strategy to Reduce Possible Food EffectView and Download
Application of a barrier membrane (BM) coating consisting of Surelease and a pore-former, Opadry.
AAPS 2011 - Effect of Drug Particle Size on Blend Segregation and Content Uniformity of Low Dose TabletsView and Download
Low dose formulations of micronized hydrochlorothiazide (HCTZ) & the effect of drug particle size and load on dissolution rate
AAPS 2012 - Barrier Membrane Coated Hydrophilic Matrices: Robustness of Metoprolol Tartrate Release under Biorelevant Test Conditions – Impact of Media CompositionView and Download
Joint poster - Ernst Moritz Arndt University & Colorcon
AAPS 2012 - Investigation of Synergistic Behavior of Excipients in Direct Compression Using a Rotary Press SimulatorView and Download
Use of Starch 1500 in combination with MCC in direct compression.
AAPS 2012 - Stability of Ethylcellulose Barrier Membrane Coated Hydrochlorothiazide Matrices Comprising Starch 1500® or Lactose as FillerView and Download
Starch 1500 contributed to robustness of the barrier membrane coated matrix tablets.
AAPS 2015 - Eliminating Burst Release of Highly Soluble Drug from Hydrophilic Matrix Tablets Using Venlafaxine as a Model DrugView and Download
Combination of ionic low viscosity polymer with high viscosity Hypromellose reduced drug release within first 2 hours of dissolution.
AAPS 2015 - Enhancing the Stability of a Famotidine Tablet Formulation through Use of Starch 1500®View and Download
The low water activity of Starch 1500 resulted in reduced degradation of famotidine. Starch/MCC formulation, coated with a PVA based Opadry® resulted in an improved accelerated stability in blister packages.
AAPS 2019 - Evaluation of Partially Pregelatinized Starch in a Continuous High Shear Wet Granulation ProcessView and Download
Poster Reprint from AAPS 2019 in San Antonio, TX, USA.
AAPS 2020 - Fundamental Evaluation of Moisture Scavenging Property of Partially Pregelatinized Maize Starch using Thermoanalytical TechniquesView and Download
AAPS 2020 - Stability Improvement of a Moisture-Sensitive Drug, Ranitidine HCl, with the Inclusion of a Partially Pregelatinized StarchView and Download
AAPS 2021 - Dissolution of Glucosamine Veterinary Chewable Tablets Using Ultra High Performance Liquid Chromatography-Charged Aerosol DetectionView and Download
CRS 2010 - Effect of Processing Conditions on Hypromellose Matrix Formulations of Acetaminophen Prepared by a High Shear Wet Granulation ProcessView and Download
Processing guidelines for developing a hypromellose matrix formulation using a wet granulation process; with extra-granular addition of HPMC and Starch 1500 resulting in increased tablet hardness.
CRS 2011 - Use of Starch 1500® to Minimize Variability on Drug Release from Hypromellose MatricesView and Download
Starch 1500 in formulation design, supporting QbD study and minimizing formulation variability
Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix TabletView and Download
The effect of various fillers on the oxidative stability of POLYOX in a matrix tablet
Published White Papers / Articles
Excipient Science in Protecting Moisture Sensitive DrugsView and Download
Formulating TCMs; East meets WestView and Download
How formulated coated tablets can make Traditional Chinese Medicine more palletable
Formulating Veterinary Chewable Tablets to Improve Palatability and AcceptanceView and Download
Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film CoatingView and Download
Combination of excipients for an aspirin tablet core suitable for aqueous enteric film coating
Formulation of Low Dose Medicines - Theory and PracticeView and Download
Evaluating multiple excipients for content uniformity in a low dose application
From Core to Coating - A Supplement from The Medicine MakerView and Download
A series of articles published in The Medicine Maker collated into a Supplement “From Core to Coating”
• Speed and Simplicity – A Formulator’s Best Friend in Development
• The Power of Productivity
• Staying On Trend
Influence of Excipients on Drug Release from Hydroxypropyl Methylcellulose MatricesView and Download
JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 93, NO. 11, Nov 2004
Multifunctional ExcipientsView and Download
Pharma Magazine Sept/Oct 2006
Starch ContrastsView and Download
Review of differences among pregelatinized starches - morphology, particle size and how the degree of modification effects functionality.
The Effect of Core Design and Formulation on the Quality of Film Coated TabletsView and Download
Article published in Pharmaceutical Technology Europe - April 2005
High Quality Tablets for Film Coating
Starch 1500 provides good tablet hardness and low friability ideal for film coating and packaging.
- Starch 1500 products are designed to meet regulatory needs worldwide.
- Starch 1500 LM: Low moisture product (less than 7% moisture). Meets PhEur and USP/NF specifications for pregelatinized starch.
- Starch 1500 G: Meets PhEur and USP/NF specifications for pregelatinized starch and JPE requirements for partly pregelatinized starch.
Contact Colorcon to learn how Starch 1500 can improve your formulation and lower your costs.