POLYOX™ Water-Soluble Resins for Pharmaceutical Applications

Antioxidant Use in POLYOX™ ER Matrices

Application of Opadry® II on metformin HCl ER matrices containing POLYOX™

Behavior of tablets containing POLYOX during coating, independent of a drug and other excipients

Dissolution Testing for POLYOX™ ER Matrices

Evaluation of Various Materials for Cleaning of Processing Area and Equipment after using POLYOX™

Formulation of POLYOX™ ER Matrices for a Highly Soluble Active

POLYOX polymers can be used as an alternative to HPMC in ER matrix tablets

Physico-mechanical Characterization of POLYOX™ for Tablet Manufacture

The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release Matrices

Techincal Bulletin: POLYOX™ Formulation

Introduction to formulation of Osmotic Push-Pull Technology using POLYOX

Technical Bulletin: POLYOX™ Manufacturing

Introduction to manufacturing and processing of Osmotic Pump technology using POLYOX

Opadry® CA - Product Information Brochure

Introduction to Opadry CA, fully formulated osmotic, one step semipermeable membrane coating system.

POLYOX™ Product Information Brochure

AAPS 2010 - Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide ER Matrix Tablets

Using model APIs robust POLYOX ER matrix tablets were produced - practically water insoluble
drug gliclazide and freely water soluble metformin HCl

AAPS 2011 - Effect of Film Coating on the Stability of ER Metformin Hydrochloride POLYOX™ Matrices

Application of PVA-based Opadry II results in enhanced tablet stability and prevented loss of mechanical strength during accelerated storage conditions

AAPS 2011 - Effect of Formulation and Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug

AAPS 2011 - Effect of Semipermeable Coating Composition and Opadry Top-Coating Systems on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug

Investigate the effect of the SPM coating, comprising cellulose acetate with different grades of polyethylene glycol(PEG)

AAPS 2011 - Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide and Hypromellose ER Matrices

Influence of ionic polymer NaCMC, on the release of model drug from ER formulations containing non-ionic polymers, PEO or HPMC, as matrix formers.

AAPS 2013 - Immediate Release Film Coating of an Acetaminophen Extended Release Matrix Tablet Containing a High Concentration of Polyethylene Oxide Water Soluble Resin

Investigation of film coating with Opadry II on hydrophilic matrix tablets

AAPS 2013 - Investigation of Direct Compression Processing of Push Layer System for Osmotic Pump Tablets

Direct Compression Processing of Push Layer System for Osmotic Pump Tablets

AAPS 2013 - Study of Dose-Weight Proportionality in Osmotic Push-Pull Technology

The purpose of this work was to formulate dose-weight proportional formulation of model drug (theophylline) at 10, 15 and 20 mg doses using standard round concave (SRC) tooling of proportional dimensions to achieve similar drug
release profiles. Surface area, volume and shape of the osmotic tablets were analyzed to further explore mechanism
of drug release.

AAPS 2015 - Eliminating Burst Release of Highly Soluble Drug from Hydrophilic Matrix Tablets Using Venlafaxine as a Model Drug

Combination of ionic low viscosity polymer with high viscosity Hypromellose reduced drug release within first 2 hours of dissolution.

APS 2010 - Influence of Polymer Concentration on Release of Poorly Soluble Drugs from Polyethylene Oxide ER Matrices

Reproducible zero and first order drug release profiles; solubility of the API and PEO concentration had an effect on drug release

CRS 2011 - Development of Push-Pull Osmotic Pump Tablets for a Slightly Water Soluble Drug

Irrespective of the multiple steps involved in manufacture, equivalent performance to commercial tablets with respect to physical properties, drug release and push-pull pattern was seen

CRS 2011 - Effect of Different Processing Conditions on the Performance of Push-Pull Osmotic Pump Tablets of a Slightly Water Soluble Drug

Effects of tablet mechanical strength, drying method of granules and methods of tablet manufacture (manual vs. rotary tablet press) on performance of PPOP tablets

CRS 2011 - The Influence of Sodium Carboxymethyl Cellulose on Drug Release from Polyethylene Oxide ER Matrices

Potential synergistic interaction can be used to design new oral ER pharmaceutical dosage forms with more
prolonged release, using lower polymer amounts

CRS 2012 - Effect of Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug

Fundamental understanding of the relationship between process variables and PPOP performance.

CRS 2012 - Influence of Cellulose Acetate Weight Gain and Solvent Ratio on Performance of Push-Pull Osmotic Pump Tablets

Effect of Opadry CA coating on the properties of push-pull osmotic pump (PPOP) tablets

CRS 2012 - Influence of Level and Location of NaCl on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug

Robustness of osmotic technology for zero order drug release and approaches to modulate drug release using the osmogen concentration and location

CRS 2012 - Investigation of Cellulose Acetate Polymer Viscosity and Coating Solution Concentration on Performance of Push-Pull Osmotic Pump (PPOP) Tablets

Critical material attributes and process parameters for consideration in development of osmotic pumps coated with Opaddry CA

CRS 2013 - Effect of Polyethylene Oxide Molecular Weight and Osmogen Content on Performance of Push-Pull Osmotic Pump Tablets

DOE determines osmogen level and interaction with POLYOX MW impacts drug release from PPOP

CRS 2014 - The Influence of Manufacturing Method on Physical Properties and Drug Release from Push-Pull Osmotic Pump (PPOP) Products

Evaluation of manufacturing methods and the impact on physical and chemical properties of granules, tablets and resulting drug release.

Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix Tablet

The effect of various fillers on the oxidative stability of POLYOX in a matrix tablet