ポリオックス™ 医薬品用途水溶性樹脂
ポリオックスTM 水溶性樹脂(NFグレード)は、非イオン性（酸化エチレン）ポリマーです。 幅広い分子量を持つ親水性ポリマーで、白色で流動性のある粉体です。ポリオックスは、オスモティックポンプ技術を含む徐放性用途において使用実績があります。
他の用途は、親水性マトリックス、胃内滞留型製剤、対タンパー性技術、経皮吸収や粘膜付着技術などの薬物送達システムを含みます。
ポリオックスTM 水溶性樹脂の利点 :
- 処方のフレキシビリティのための幅広い分子量レンジ
- 直接打錠と造粒における多用途にわたる応用
- オスモティックポンプ技術のための迅速な水和と膨張
- 親水性マトリックスのための迅速な水和とゲル形成
- 対タンパー性技術のための極度の硬さおよびつぶれにくい
カラコンは、IFFの放出制御に使用されるポリオックスTM製品に関するグローバルの独占販売権を所有しています。
POLYOX™ is a trademark of International Flavors and Fragrances Inc. or its affiliates. © 2021 IFF. All rights reserved
プロダクトアプリケーションデータ
Application of Opadry® II on metformin HCl ER matrices containing POLYOX™
ドキュメントのダウンロード 電子メールで送信Behavior of tablets containing POLYOX during coating, independent of a drug and other excipients
Evaluation of Various Materials for Cleaning of Processing Area and Equipment after using POLYOX™
ドキュメントのダウンロード 電子メールで送信Formulation of POLYOX™ ER Matrices for a Highly Soluble Active
ドキュメントのダウンロード 電子メールで送信POLYOX polymers can be used as an alternative to HPMC in ER matrix tablets
The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release Matrices
ドキュメントのダウンロード 電子メールで送信一般的な情報
Techincal Bulletin: POLYOX™ Formulation
ドキュメントのダウンロード 電子メールで送信Introduction to formulation of Osmotic Push-Pull Technology using POLYOX
Technical Bulletin: POLYOX™ Manufacturing
ドキュメントのダウンロード 電子メールで送信Introduction to manufacturing and processing of Osmotic Pump technology using POLYOX
製品カタログ
Opadry® CA - Product Information Brochure
ドキュメントのダウンロード 電子メールで送信Introduction to Opadry CA, fully formulated osmotic, one step semipermeable membrane coating system.
ポスター
AAPS 2010 - Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide ER Matrix Tablets
ドキュメントのダウンロード 電子メールで送信Using model APIs robust POLYOX ER matrix tablets were produced - practically water insoluble
drug gliclazide and freely water soluble metformin HCl
AAPS 2011 - Effect of Film Coating on the Stability of ER Metformin Hydrochloride POLYOX™ Matrices
ドキュメントのダウンロード 電子メールで送信Application of PVA-based Opadry II results in enhanced tablet stability and prevented loss of mechanical strength during accelerated storage conditions
AAPS 2011 - Effect of Formulation and Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug
ドキュメントのダウンロード 電子メールで送信AAPS 2011 - Effect of Semipermeable Coating Composition and Opadry Top-Coating Systems on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug
ドキュメントのダウンロード 電子メールで送信Investigate the effect of the SPM coating, comprising cellulose acetate with different grades of polyethylene glycol(PEG)
AAPS 2011 - Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide and Hypromellose ER Matrices
ドキュメントのダウンロード 電子メールで送信Influence of ionic polymer NaCMC, on the release of model drug from ER formulations containing non-ionic polymers, PEO or HPMC, as matrix formers.
AAPS 2013 - Immediate Release Film Coating of an Acetaminophen Extended Release Matrix Tablet Containing a High Concentration of Polyethylene Oxide Water Soluble Resin
ドキュメントのダウンロード 電子メールで送信Investigation of film coating with Opadry II on hydrophilic matrix tablets
AAPS 2013 - Investigation of Direct Compression Processing of Push Layer System for Osmotic Pump Tablets
ドキュメントのダウンロード 電子メールで送信Direct Compression Processing of Push Layer System for Osmotic Pump Tablets
AAPS 2013 - Study of Dose-Weight Proportionality in Osmotic Push-Pull Technology
ドキュメントのダウンロード 電子メールで送信The purpose of this work was to formulate dose-weight proportional formulation of model drug (theophylline) at 10, 15 and 20 mg doses using standard round concave (SRC) tooling of proportional dimensions to achieve similar drug
release profiles. Surface area, volume and shape of the osmotic tablets were analyzed to further explore mechanism
of drug release.
AAPS 2015 - Eliminating Burst Release of Highly Soluble Drug from Hydrophilic Matrix Tablets Using Venlafaxine as a Model Drug
ドキュメントのダウンロード 電子メールで送信Combination of ionic low viscosity polymer with high viscosity Hypromellose reduced drug release within first 2 hours of dissolution.
AAPS 2023 - Preparation of Osmotic Tablets Using a Direct-to-Hopper Formulated Push Layer Based on Polyethylene Oxide
ドキュメントのダウンロード 電子メールで送信APS 2010 - Influence of Polymer Concentration on Release of Poorly Soluble Drugs from Polyethylene Oxide ER Matrices
ドキュメントのダウンロード 電子メールで送信Reproducible zero and first order drug release profiles; solubility of the API and PEO concentration had an effect on drug release
CRS 2011 - Development of Push-Pull Osmotic Pump Tablets for a Slightly Water Soluble Drug
ドキュメントのダウンロード 電子メールで送信Irrespective of the multiple steps involved in manufacture, equivalent performance to commercial tablets with respect to physical properties, drug release and push-pull pattern was seen
CRS 2011 - Effect of Different Processing Conditions on the Performance of Push-Pull Osmotic Pump Tablets of a Slightly Water Soluble Drug
ドキュメントのダウンロード 電子メールで送信Effects of tablet mechanical strength, drying method of granules and methods of tablet manufacture (manual vs. rotary tablet press) on performance of PPOP tablets
CRS 2011 - The Influence of Sodium Carboxymethyl Cellulose on Drug Release from Polyethylene Oxide ER Matrices
ドキュメントのダウンロード 電子メールで送信Potential synergistic interaction can be used to design new oral ER pharmaceutical dosage forms with more
prolonged release, using lower polymer amounts
CRS 2012 - Effect of Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug
ドキュメントのダウンロード 電子メールで送信Fundamental understanding of the relationship between process variables and PPOP performance.
CRS 2012 - Influence of Cellulose Acetate Weight Gain and Solvent Ratio on Performance of Push-Pull Osmotic Pump Tablets
ドキュメントのダウンロード 電子メールで送信Effect of Opadry CA coating on the properties of push-pull osmotic pump (PPOP) tablets
CRS 2012 - Influence of Level and Location of NaCl on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug
ドキュメントのダウンロード 電子メールで送信Robustness of osmotic technology for zero order drug release and approaches to modulate drug release using the osmogen concentration and location
CRS 2012 - Investigation of Cellulose Acetate Polymer Viscosity and Coating Solution Concentration on Performance of Push-Pull Osmotic Pump (PPOP) Tablets
ドキュメントのダウンロード 電子メールで送信Critical material attributes and process parameters for consideration in development of osmotic pumps coated with Opaddry CA
CRS 2013 - Effect of Polyethylene Oxide Molecular Weight and Osmogen Content on Performance of Push-Pull Osmotic Pump Tablets
ドキュメントのダウンロード 電子メールで送信DOE determines osmogen level and interaction with POLYOX MW impacts drug release from PPOP
CRS 2014 - The Influence of Manufacturing Method on Physical Properties and Drug Release from Push-Pull Osmotic Pump (PPOP) Products
ドキュメントのダウンロード 電子メールで送信Evaluation of manufacturing methods and the impact on physical and chemical properties of granules, tablets and resulting drug release.
Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix Tablet
ドキュメントのダウンロード 電子メールで送信The effect of various fillers on the oxidative stability of POLYOX in a matrix tablet
ホワイトペーパー/記事
Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide ER Matrix Tablets
ドキュメントのダウンロード 電子メールで送信Pharmaceutical Technology Europe - July 2011
