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Picking and Sticking

Tablet Core

  • Poor adhesion to core Use high adhesion core excipients

Coating Formulation

  • Poor film adhesion Select a high adhesion film coating from Colorcon
  • Low solids film coating formulation Select a high solids film coating from Colorcon

Process/Equipment

  • Spray rate too high Decrease spray rate
  • Drying air volume too low Increase airflow rate
  • Drying air temperature too low Increase drying temperature
  • Pan speed too low Increase pan speed
  • Atomization air pressure too low Increase atomization air pressure
  • Pan load too low Increase pan load
  • Poor spray uniformity Increase number of spray guns, fan width and/or gun-to-bed distance, suspension flow rate balance

Further Resources