Acryl-EZE® Aqueous Acrylic Enteric System
Acryl-EZE®, aqueous enteric systems are a range of fully formulated, high performance coatings that provide pH targeted resistance. The formulations are designed for use on tablets or multiparticulate solid oral dosage products, including proton pump inhibitor (PPI) applications.
Targeted pH Applications
Acryl-EZE is convenient for use, presenting significant time savings in development and production, and protects against acidic conditions and fast release in buffer (small intestinal fluids) conditions.. Available for use with choice of plasticizer for application flexibility and customization.
Acryl-EZE II is an optimized high performance coating that offers enteric protection in the intermediate pH range media, suitable for proton pump inhibitor (PPI) applications and provides enteric protection at lower weight gains compared to Acryl-EZE systems.
Product LiteratureGeneral Information Product Process Parameters Product Recon Sheet Product Brochure Published Posters
Acryl-EZE® 93A Product InformationView and Download
93A series key characteristics, applications, packaging, storage and reevaluation information.
Acryl-EZE® Enteric Coating StabilityView and Download
Stability information for Acryl-EZE coated, delayed release aspirin tablets, at ambient and accelerated storage conditions.
Acryl-EZE® MP Product InformationView and Download
Acryl-EZE MP series key characteristics, applications, packaging, storage and reevaluation information.
Acryl-EZE® Product StabilityView and Download
Stability information for reconstituted Acryl-EZE powder formulations at ambient and accelerated storage conditions.
Product Process Parameters
Acryl-EZE® Coating ParametersView and Download
Recommended coating process parameters for Acryl-EZE in laboratory, pilot, and production scale coating pans.
Acryl-EZE® II Coating Parameters – Multiparticulate ApplicationsView and Download
Recommended coating process parameters for Acryl-EZE II on Multiparticulates
Acryl-EZE® II Coating Parameters – Tablet ApplicationsView and Download
Recommended coating process parameters for Acryl-EZE II on Tablets
Acryl-EZE® MP Coating ParametersView and Download
Recommended coating process parameters for Acryl-EZE MP in laboratory and pilot scale fluid bed coaters.
Product Recon Sheet
Acryl-EZE® 93A Preparation and Use SheetView and Download
Recommended dispersion mixing procedures, coating levels, and cleaning guidelines.
Acryl-EZE® II Preparation and Use SheetView and Download
Outline of the recommended dispersion mixing procedures for tablets or multiparticulates including coating levels, and cleaning guidelines
Acryl-EZE® MP Preparation and Use SheetView and Download
Outline of the recommended dispersion mixing procedures, coating levels, and cleaning guidelines for Acryl-EZE MP.
Acryl-EZE® Preparation and Use SheetView and Download
Outline of the recommended dispersion mixing procedures, coating levels, and cleaning guidelines.
AAPS 2000 - Acryl-EZE® Optimal Coating ParametersView and Download
Development of the optimum coating process parameters for Acryl-EZE dispersions.
AAPS 2001 - Preparation of an Enteric Dosage Form with a Water-Dispersible Acrylic Film Coating FormulationView and Download
Stability information for the Acryl-EZE® formulation including application to enteric-coated aspirin tablets.
AAPS 2001 - Production-Scale Process and Performance Comparison of Two Fully-Formulated Aqueous Enteric Coating SystemsView and Download
Summary of the production scale evaluation of Acryl-EZE® and Sureteric® for coating process, enteric protection, and finished product stability.
AAPS 2002 - Preparation of Robust, Enteric-Coated Dosage FormsView and Download
Solutions for the application of aluminum lake pigmented Acryl-EZE formulations onto various actives, to provide stable, reproducible drug release.
AAPS 2005 - Investigation of a Modified USP Disintegration Test Method for Enteric Coated TabletsView and Download
Outline of the method and rationale for the analysis of enteric-coated dosage forms in intermediate acidic pH conditions (pH 4.5).
AAPS 2005 - New Coating Process for the Application of Enteric Coatings to Small Tablet SamplesView and Download
Investigation of a rapid application of an aqueous enteric coating system onto very small batch sizes of tablets using a novel coating process technology, the SUPERCELL™ process from Niro.
AAPS 2005 - The Effect of Superdisintegrant on Acid Resistance of Enteric Coated TabletsView and Download
Investigation of the influence of superdisintegrant type and level on the performance of two enteric coated tablet formulations.
AAPS 2005 - The Influence of Gastric Media (In-Vitro) on the Performance of Delayed Release Proton Pump Inhibitor Dosage FormsView and Download
Invstigation of the enteric performance of aqueous enteric-coated tablet formulations containing proton pump inhibitors (PPI’s) in bio-relevant media, better simulating the gastric environment of a patient on a multiple dose regimen of PPI’s.
AAPS 2006 - Application of Powder Layering Technology and Aqueous Enteric CoatingView and Download
Study of Acryl-EZE 93 series when applied onto dry powder layered lansoprazole multiparticulates.
AAPS 2006 - Aqueous Enteric Coating Application on Non-Banded Hard Gelatin CapsulesView and Download
Investigation of the delayed release performance of 93 series, when applied onto omeprazole filled, hard gelatin capsules.
AAPS 2008 - Evaluation of the Enteric Performance of Lansoprazole Mini-Tabs Coated in a Perforated PanView and Download
The focus of this study was to investigate the potential of successful manufacture and enteric coating of lansoprazole mini-tabs using methacrylic acid co-polymers in a perforated pan. Along with other findings, this study will show that the mechanical strength of the mini-tabs significantly improved upon application of a seal-coat.
AAPS 2008 - Formulation and Process Considerations for Delayed Release Multi-Particulates of Esomeprazole MagnesiumView and Download
Study of the application process for an enteric coating systemon an esomeprazole magnesium trihydrate (40 mg) multi-particulate system.
AAPS 2009 - The Influence of In Vitro Dissolution Method on Lansoprazole Release from Enteric Coated Mini-TabsView and Download
Study of the Influence of In Vitro Dissolution Method on Lansoprazole Release from Enteric Coated Mini-Tabs
AAPS 2010 - Effects of Core Tablet Size on the Functionality of Aqueous Delayed Release Coatings as Measured by SEM and LIBSView and Download
The aim of this work was to develop a correlation between tablet surface area (size) and the minimum amount of coating weight gain/thickness of a functional coating necessary for enteric protection of tablets. The film coat thickness was determined via scanning electron microscopy (SEM) and laser-induced breakdown spectroscopy (LIBS).Acryl-EZE 93O formulations
AAPS 2013 - Investigaton of a New Semi-continuous Coating Process Using a Fully Formlated Enteric Coating SystemView and Download
Examining the suitability of the Omega novel semi-continuous coating process with a model Acryl-EZE enteric release coating system.
AAPS 2018 - Enhanced Intra Tablet Enteric Coating Uniformity in the ConsiGma™ Coating ProcessView and Download
AAPS 2020 - In Vitro Evaluation of an Enteric Coating System for Esomeprazole Delayed Release Multiparticulates for Administration Through Nasogastric TubeView and Download
AAPS 2020 - Postprandial Enteric Performance of Enteric Coated Omeprazole Multiparticulate SystemsView and Download
AAPS 2021 - Investigation of a Directly Compressible Pantoprazole Sodium Delayed Release FormulationView and Download
CRS 2001 - Performance Characteristics of Acryl-EZE®View and Download
Comparison of the performance of the Acryl-EZE fully formulated system versus a multiple step dispersion preparation of Eudragit L100-55.
CRS 2003 - Preparation of Stable, Gastro-Resistant Diclofenac Sodium Tablets, Utilizing Optimized Film-Coating CombinationsView and Download
Demonstration of how to reduce overall coating process time and achieve drug product stability, by incorporating pigments directly into the Acryl-EZE enteric film layer.
CRS 2004 - Enteric Coating of Tablets with Debossed LogosView and Download
This ADS was adapated from the 2004 CRS poster demonstrating how to successfully enteric coat tablets which contain a debossed logo.
CRS 2006 - Controlled Permeability Films for Programmable Drug ReleaseView and Download
Investigation of the influence of sodium alginate or hypromellose (HPMC) as pore formers in a delayed release film coating to achieve modified enteric drug release.
CRS 2006 - In-vitro Dissolution Testing of Delayed Release Multi-Particulate SystemsView and Download
This poster study was to investigate the use of fumed silica as an anti-adherent agent to prevent potential agglomeration of multi-particulates in acid media.
CRS 2007 - The Influence of Plasticizer Type and Concentration on Acid Resistance of Coated TabletsView and Download
Investigation of the influence of plasticizer type and concentration on acid resistance, when added to Acryl-EZE® 93A, aqueous delayed-release (DR) film coating systems.
CRS 2008 - Investigation of Enteric Coating of Min-tabs Using a Perforated Pan or a Fluid-bed MachineView and Download
Feasibility study of using a perforated coating pan evaluated and compared to a fluid-bed machine. Differences between the two processes, in terms of coated tablet appearance, physical properties and enteric protection were studied.
CRS 2010 - A Comparison of Delayed Release Film Coating Systems for Pharmaceutical Dosage FormsView and Download
This study compares the dispersion properties, film properties and enteric performance at varying pH conditions, of four commercially available aqueous,delayed release film coating systems.
CRS 2018 - Simultaneous Application of a Two-part Delayed Release Coating in a Single Pass Continuous Coating ProcessView and Download
Save Time in Development and Production
- Fully formulated, complete system
- Simple to dispense and disperse (20 minutes), with easy clean up
- Reduced raw material inventory and QC requirements
- Suitable for use on tablets, granules, multiparticulates
- Performance validated through in vivo studies