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METHOCEL™ Premium DC2 Cellulose Ethers
Available as directly compressible grades, METHOCEL™ DC2 polymers deliver exceptional flow properties and process capability as well as consistent modified release performance for matrix formulations. METHOCEL™ DC2 enable manufacturers to replace costly wet granulation in matrix tablet production with cost effective dry granulation and direct compression techniques.
METHOCEL™ DC2 helps you enjoy the benefits of dry powder processing techniques:
- improved powder flow
- lower manufacturing costs by up to 60%
- shorten development time
- results in more reproducible and robust tablet properties
- better formulation option for heat and moisture-sensitive APIs
- no additives, means no regulatory hurdles, as METHOCEL™ DC2 is pure HPMC
Two direct compression grades of METHOCEL™ DC2 are available: K100 LV, and K100M; chemically identical to current METHOCEL™ Premium products and meet USP, PhEur and JP specifications.
Colorcon, through the Controlled Release Alliance, has exclusive, global sales and distribution rights for METHOCEL™ products from IFF for use in controlled release applications.
METHOCEL™ is a trademark of International Flavors and Fragrances Inc. or its affiliates. © 2021 IFF. All rights reservedProduct Literature
Product Application Data General Information Product Brochure Published Posters Published White Papers / ArticlesProduct Application Data
Formulation of an Extended Release Melatonin Dietary Supplement
View and Download Send by EmailDue to melatonin's short half-life, nutra companies face a challenge designing extended release tablets. Learn how hypromellose may be a solution.
Maintaining Similar Drug Release from Hypromellose Matrices with Identical Dimensions but Different Dose Strengths
View and Download Send by EmailMethod to maintain similar drug release, tablet shape and weight, from a METHOCEL matrix, while adjusting the drug dose.
METHOCEL™ DC2: Designed for Speed, Simplicity and Performance
View and Download Send by EmailMETHOCEL™ DC2 Technical Application Sheet
Technical Bulletin:Film Coating of Hydrophilic Matrices
View and Download Send by EmailFilm Coating of Hydrophilic Matrix Tablets : Safety Considerations for Product Design to Minimize Medication Errors
General Information
Quality by Design (QbD) for METHOCEL™ Premium CR Cellulose Ethers
View and Download Send by EmailIntroduction to QbD initiatives for the robust design of product and manufacturing process of hydrophilic matrices.
Product Brochure
METHOCEL™ DC2 Product Information Brochure
View and Download Send by EmailMETHOCEL DC2 Premium Excipients help you enjoy the benefits of dry powder processing techniques
while maintaining consistent modified release performance. They offer the performance and reliability expected from the proven family of METHOCEL™ excipients.
Using METHOCEL™ Cellulose Ethers for Controlled Release of Drugs in Hydrophilic Matrix Systems
View and Download Send by EmailPublished Posters
CRS 2011 - Use of Starch 1500® to Minimize Variability on Drug Release from Hypromellose Matrices
View and Download Send by EmailStarch 1500 in formulation design, supporting QbD study and minimizing formulation variability
CRS 2012 - Barrier Membrane Coating of Hydrophilic Matrices of a Very Soluble Drug, Metoprolol Tartrate at High Dose: A Strategy to Eliminate the Initial Burst Release
View and Download Send by EmailApplication of barrier membrane (BM) coating, using Surelease with a pore-former, Opadry; elimination of the burst effect, followed by near zero order release.
CRS 2013 - Barrier Membrane Coating of Hydrophilic Matrices: A Simplified Strategy to Attain Zero Order Drug Release
View and Download Send by EmailAlternative formulation strategy for dosage forms where zero order release of drug is desired
Published White Papers / Articles
Streamline Manufacture of Modified Release Matrix Tablets via Direct Compression
View and Download Send by EmailIn this whitepaper, we describe how to get to market faster with directly compressible hypromellose (HPMC), which bypasses time-consuming and labor-intensive wet granulation, saves processing time and cost, and lowers regulatory hurdles due to reduced manufacturing steps and complexity.
Platform Solutions
Colorcon can help to reduce your project time by providing the right solution through excipient selection and process guidance.
Productivity
Lower total cost and reduce time to market
Dissolution Design
Life cycle management through modified delivery profiles and product line extensions
Patient Adherence
Reduce medication errors and improve patient adherence
Stability
Stable and consistent product performance
Product Authentication
Track and trace