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Starch 1500® Partially Pregelatinized Maize Starch
Starch 1500 is a proven and trusted unique excipient, manufactured exclusively for the global pharmaceutical and nutritional industries.
- Stabilizes moisture sensitive drugs and active ingredients
- Provides excellent low dose content uniformity
- Meets regulatory standards
In addition to providing a unique range of functions and flexible performance in a variety of applications, Starch 1500 cuts process and material costs by reducing or eliminating binders, superdisintegrants, high levels of lubricants and glidants.
Product Literature
Product Application Data General Information Product Brochure Published Posters Published White Papers / ArticlesProduct Application Data
AAPS 2024 - Effect of Mixing Time and Mixing Process on Lubricant Sensitivity of Excipients with Different Deformation Characteristics
View and Download Send by EmailAssessment of Low Dose Content Uniformity of Indomethacin
View and Download Send by EmailComparison of excipients and content uniformity in a formula containing a very low dose of indomethacin
Direct Compression Formulation of Loratadine (10 mg) Tablets
View and Download Send by EmailStarch 1500 in a lactose free, low dose active formulation, loratadine
Formulation of an Extended Release Melatonin Dietary Supplement
View and Download Send by EmailDue to melatonin's short half-life, nutra companies face a challenge designing extended release tablets. Learn how hypromellose may be a solution.
Formulation of Veterinary Chewable Tablets
View and Download Send by EmailFormulation of Veterinary Chewable Tablets - Case Study with Carprofen
Increasing the Compactability of Echinacea Purpurea Powder using Starch 1500®
View and Download Send by EmailTreating a high dose, poorly compressible herbal powder with Starch 1500 and fumed silica to increase compressibility
Lactose Replacement with Starch 1500® in a direct compression formula
View and Download Send by EmailRobust, more stable placebo tablet via DC compared to a similar lactose based formulation
Replacement of Di Basic Calcium Phosphate with Starch 1500® in a DC Formula
View and Download Send by EmailBenefits of using Starch 1500 in a DC placebo formulation replacing DCP
Starch 1500® as a Binder and Disintegrant in XCH (Xiaochaihu) Herbal Extract/Powder Tablet
View and Download Send by EmailHigh dose tablet formulation of XCH herbal extract/powder combination using Starch 1500/MCC in a high-shear granulation process
Starch 1500® used as a Binder Disintegrant in High Shear Wet Granulation Comparison to Povidone and Croscarmellose Sodium
View and Download Send by EmailStarch 1500 reduces overall cost and complexity of a formulation, in comparison to povidone and croscarmellose sodium
Wet Granulation of Acetaminophen with Starch 1500®
View and Download Send by EmailImprovement in tablet hardness and disintegration of Starch 1500 vs PVP
General Information
Free and Bound Water in Starch 1500® compared to other excipients
View and Download Send by EmailComparison of Water Activity vs LOD of commonly used excipients.
Improving the Stability of a Moisture-Sensitive Drug - Ranitidine HCl
View and Download Send by EmailTechnical Bulletin: Starch 1500®
View and Download Send by EmailTypical properties and key applications for Starch 1500 in oral solid dose formulation
Product Brochure
Starch 1500® Product Brochure
View and Download Send by EmailIntroduction to Starch 1500 partially pregelatinized maize starch. Proven and Trusted Excipient for Performance and Versatility.
Published Posters
AAPS 2005 - Particle Swelling and Coalescence to Gel Layer Formation
View and Download Send by EmailSwelling and coalescence behavior of HPMC and Starch 1500, in order to monitor the contribution to gel layer formation in matrices.
AAPS 2006 - Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst Effect
View and Download Send by EmailMethod to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL matrices.
AAPS 2008 - Narrowing the Gap Between Clinical and Commercial Formulations
View and Download Send by EmailDeveloping a single formula that can be encapsulated into hard gelatin capsules for clinical studies and compressed into tablets for commercialization.
AAPS 2010 - Effect of Filler Type on Low Dose Acetaminophen Hydrophilic Matrix Formulations
View and Download Send by EmailEffect of four commonly used fillers in formulation and processing of HPMC matrices utilizing a high shear wet granulation process.
AAPS 2010 - Influence of Filler Type in the Blend Uniformity of Micronized Drugs
View and Download Send by EmailChoice of filler for a low-dose micronized drug to assist dispersibility and uniformity of the drug
AAPS 2011 - Barrier Membrane Coating of Hydrophilic Matrices of Sparingly Soluble Drug, Acetaminophen: A Strategy to Reduce Possible Food Effect
View and Download Send by EmailApplication of a barrier membrane (BM) coating consisting of Surelease and a pore-former, Opadry.
AAPS 2011 - Effect of Drug Particle Size on Blend Segregation and Content Uniformity of Low Dose Tablets
View and Download Send by EmailLow dose formulations of micronized hydrochlorothiazide (HCTZ) & the effect of drug particle size and load on dissolution rate
AAPS 2012 - Barrier Membrane Coated Hydrophilic Matrices: Robustness of Metoprolol Tartrate Release under Biorelevant Test Conditions – Impact of Media Composition
View and Download Send by EmailJoint poster - Ernst Moritz Arndt University & Colorcon
AAPS 2012 - Investigation of Synergistic Behavior of Excipients in Direct Compression Using a Rotary Press Simulator
View and Download Send by EmailUse of Starch 1500 in combination with MCC in direct compression.
AAPS 2012 - Stability of Ethylcellulose Barrier Membrane Coated Hydrochlorothiazide Matrices Comprising Starch 1500® or Lactose as Filler
View and Download Send by EmailStarch 1500 contributed to robustness of the barrier membrane coated matrix tablets.
AAPS 2015 - Eliminating Burst Release of Highly Soluble Drug from Hydrophilic Matrix Tablets Using Venlafaxine as a Model Drug
View and Download Send by EmailCombination of ionic low viscosity polymer with high viscosity Hypromellose reduced drug release within first 2 hours of dissolution.
AAPS 2015 - Enhancing the Stability of a Famotidine Tablet Formulation through Use of Starch 1500®
View and Download Send by EmailThe low water activity of Starch 1500 resulted in reduced degradation of famotidine. Starch/MCC formulation, coated with a PVA based Opadry® resulted in an improved accelerated stability in blister packages.
AAPS 2019 - Evaluation of Partially Pregelatinized Starch in a Continuous High Shear Wet Granulation Process
View and Download Send by EmailPoster Reprint from AAPS 2019 in San Antonio, TX, USA.
AAPS 2020 - Fundamental Evaluation of Moisture Scavenging Property of Partially Pregelatinized Maize Starch using Thermoanalytical Techniques
View and Download Send by EmailAAPS 2020 - Stability Improvement of a Moisture-Sensitive Drug, Ranitidine HCl, with the Inclusion of a Partially Pregelatinized Starch
View and Download Send by EmailAAPS 2021 - Dissolution of Glucosamine Veterinary Chewable Tablets Using Ultra High Performance Liquid Chromatography-Charged Aerosol Detection
View and Download Send by EmailAAPS 2022 - The Effect of a Clean-Label, Plant-Based Natural Glidant on the Flow Properties of Multiple Model Powders Compared to a Synthetic Glidant
View and Download Send by EmailAAPS Poster Reprint 2022
CRS 2010 - Effect of Processing Conditions on Hypromellose Matrix Formulations of Acetaminophen Prepared by a High Shear Wet Granulation Process
View and Download Send by EmailProcessing guidelines for developing a hypromellose matrix formulation using a wet granulation process; with extra-granular addition of HPMC and Starch 1500 resulting in increased tablet hardness.
CRS 2011 - Use of Starch 1500® to Minimize Variability on Drug Release from Hypromellose Matrices
View and Download Send by EmailStarch 1500 in formulation design, supporting QbD study and minimizing formulation variability
Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix Tablet
View and Download Send by EmailThe effect of various fillers on the oxidative stability of POLYOX in a matrix tablet
Published White Papers / Articles
Formulating TCMs; East meets West
View and Download Send by EmailHow formulated coated tablets can make Traditional Chinese Medicine more palletable
Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film Coating
View and Download Send by EmailCombination of excipients for an aspirin tablet core suitable for aqueous enteric film coating
Formulation of Low Dose Medicines - Theory and Practice
View and Download Send by EmailEvaluating multiple excipients for content uniformity in a low dose application
From Core to Coating - A Supplement from The Medicine Maker
View and Download Send by EmailA series of articles published in The Medicine Maker collated into a Supplement “From Core to Coating”
• Speed and Simplicity – A Formulator’s Best Friend in Development
• The Power of Productivity
• Staying On Trend
Influence of Excipients on Drug Release from Hydroxypropyl Methylcellulose Matrices
View and Download Send by EmailJOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 93, NO. 11, Nov 2004
Starch Contrasts
View and Download Send by EmailReview of differences among pregelatinized starches - morphology, particle size and how the degree of modification effects functionality.
The Effect of Core Design and Formulation on the Quality of Film Coated Tablets
View and Download Send by EmailArticle published in Pharmaceutical Technology Europe - April 2005
High Quality Tablets for Film Coating
Starch 1500 provides good tablet hardness and low friability ideal for film coating and packaging.
Product Range
- Starch 1500 products are designed to meet regulatory needs worldwide.
- Starch 1500 LM: Low moisture product (less than 7% moisture). Meets PhEur and USP/NF specifications for pregelatinized starch.
- Starch 1500 G: Meets PhEur and USP/NF specifications for pregelatinized starch and JPE requirements for partly pregelatinized starch.
Contact Colorcon to learn how Starch 1500 can improve your formulation and lower your costs.
Platform Solutions
Colorcon can help to reduce your project time by providing the right solution through excipient selection and process guidance.
Productivity
Lower total cost and reduce time to market
Dissolution Design
Life cycle management through modified delivery profiles and product line extensions
Patient Adherence
Reduce medication errors and improve patient adherence
Stability
Stable and consistent product performance
Product Authentication
Track and trace