AAPS 2013 - Study of Dose-Weight Proportionality in Osmotic Push-Pull Technology

The purpose of this work was to formulate dose-weight proportional formulation of model drug (theophylline) at 10, 15 and 20 mg doses using standard round concave (SRC) tooling of proportional dimensions to achieve similar drug
release profiles. Surface area, volume and shape of the osmotic tablets were analyzed to further explore mechanism
of drug release.