Starch 1500® Partially Pregelatinized Maize Starch is used as a binder and/or a disintegrant in wet granulated formulations. It is well suited for use in fluid bed granulation, in addition to low shear and high shear wet granulation. Starch 1500 can reduce process time and cost while preserving optimal properties in a well designed formulation. As a binder and disintegrant in wet granulation Starch 1500 offers process flexiblity due to the low solution viscosity, binding and disintegration properties.
- The cold water soluble fraction of Starch 1500 provides unique benefits for the granulation process. The main advantage is that it can be dry blended with other ingredients and granulation can be accomplished by the addition of water.
- Simplifies the process by eliminating the need to prepare binder slurries.
- Reduces the risk of over-granulation, while providing the formulation with an effective intragranular disintegrant.
- A slurry of Starch 1500 in cold water provides effective binding properties at higher solids and lower viscosity than traditional starch pastes. Processing costs are reduced by eliminating the time and expense of preparing traditional binder solutions. In addition, granulations using Starch 1500 as a binder give excellent tablet hardness and fast disintegration.
METHOCEL™ Premium LV Cellulose Ethers may be employed as binders in the wet granulation of tablet products at a level of 3-5% of finished tablet weight.
- Produces strong granules of uniform size.
- METHOCEL E15LV produces stronger granules compared to those made with E5 LV.
- Enables the reduction of compression force, an important factor in extending the life of tooling and equipment.
METHOCEL™ is a trademark of The Dow Chemical Company
Product Application Data
- Increasing the Compactability of Echinacea Purpurea Powder using Starch 1500®
- Starch 1500® as a Binder and Disintegrant in XCH (Xiaochaihu) Herbal Extract/Powder Tablet
- Starch 1500® used as a Binder Disintegrant in High Shear Wet Granulation Comparison to Povidone and Croscarmellose Sodium
- Wet Granulation of Acetaminophen with Starch 1500®
- AAPS 2008 - Application of Surelease® in Preparation of Theophylline Extended Release Inert Matrix Tablets by Spray Granulation
- CRS 2011 - Development of Push-Pull Osmotic Pump Tablets for a Slightly Water Soluble Drug
- CRS 2011 - Effect of Different Processing Conditions on the Performance of Push-Pull Osmotic Pump Tablets of a Slightly Water Soluble Drug
- CRS 2012 - Effect of Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug
- CRS 2012 - Influence of Cellulose Acetate Weight Gain and Solvent Ratio on Performance of Push-Pull Osmotic Pump Tablets
- CRS 2012 - Influence of Level and Location of NaCl on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model Drug
- CRS 2012 - Investigation of Cellulose Acetate Polymer Viscosity and Coating Solution Concentration on Performance of Push-Pull Osmotic Pump (PPOP) Tablets
- CRS 2014 - The Influence of Manufacturing Method on Physical Properties and Drug Release from Push-Pull Osmotic Pump (PPOP) Products