Direct compression is the simplest and most economical method to manufacture tablets; with active pharmaceutical ingredients (API) being blended with other directly compressible ingredients.
Colorcon offers several directly compressible excipients for developing immediate release and controlled release pharmaceutical tablets.
Product Application Data
- Direct Compression Formulation of Loratadine (10 mg) Tablets
- Direct Compression using Starch 1500® with Ranitidine HCL (150mg) Tablets, Film Coated with Opadry II
- Lactose Replacement with Starch 1500® in a direct compression formula
- Maintaining Similar Drug Release from Hypromellose Matrices with Identical Dimensions but Different Dose Strengths
- Replacement of Di Basic Calcium Phosphate with Starch 1500® in a DC Formula
- AAPS 2008 - Investigation of Ethylcellulose in the Preparation of Theophylline ER Inert Matrix Tablets
- AAPS 2012 - Investigation of Synergistic Behavior of Excipients in Direct Compression Using a Rotary Press Simulator
- AAPS 2013 - Investigation of Direct Compression Processing of Push Layer System for Osmotic Pump Tablets
- CRS 2011 - The Influence of Sodium Carboxymethyl Cellulose on Drug Release from Polyethylene Oxide ER Matrices
- CRS 2011 - Use of Starch 1500® to Minimize Variability on Drug Release from Hypromellose Matrices
- CRS 2014 - The Influence of Manufacturing Method on Physical Properties and Drug Release from Push-Pull Osmotic Pump (PPOP) Products
- Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix Tablet