Drug Layering Substrates
Multiparticulate drug delivery systems are increasing as pharmaceutical companies seek to improve clinical effectiveness, extend product life cycle and meet the needs for different age populations. Sugar spheres, as an inert starting substrate, provide a reliable platform for drug loading.
The selection of the right sugar sphere is a crucial part of the formulation, so it’s important to understand the critical success factors for drug loading:
- Surface roughness and sphericity to ensure uniform application
- Reliable and reproducible uniformity for batch-to-batch consistency
- Range of particle sizes to meet different dose levels
- Low friability and hardness to withstand the rigors of processing
SUGLETS® Sugar Spheres are ideal for use in production of sustained, delayed or time-release formulations.
To ensure consistent product for pharmaceutical use it’s important to choose a highly reputable supplier of pharmaceutical excipients. Colorcon manufactures sugar spheres to comply with specifications as outlined in the current version of the USP/NF and PhEur and in compliance with applicable excipient GMP requirements based on the USP/NF General Chapter and Good Manufacturing Processes for Bulk Pharmaceutical. They also meet all specifications for sugar spheres as outlined in the current version of USP /NF, JPE and PhEur.
- AAPS 2014 - Evaluation of a Process Relevant Method for Determining the Robustness of a Sugar Sphere Drug Layering Substrate
- AAPS 2016 Optimization of Extrusion Spheronization Process for Multiparticulates via Design of Experiments
- CRS 2009 - Influence of Mol. Wt. on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
- CRS 2009 - Influence of Plasticizer Type and Level on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
- CRS 2016 - Study of Dose-Weight Proportionality in Extended Release Multiparticulate Systems Different
- CRS 2016 - Why Choose Small Sugar Spheres