Drug Layering Substrates

Multiparticulate drug delivery systems are increasing as pharmaceutical companies seek to improve clinical effectiveness, extend product life cycle and meet the needs for different age populations. Sugar spheres, as an inert starting substrate, provide a reliable platform for drug loading.

The selection of the right sugar sphere is a crucial part of the formulation, so it’s important to understand the critical success factors for drug loading:

  • Surface roughness and sphericity to ensure uniform application
  • Reliable and reproducible uniformity for batch-to-batch consistency
  • Range of particle sizes to meet different dose levels
  • Low friability and hardness to withstand the rigors of processing

SUGLETS® Sugar Spheres are ideal for use in production of sustained, delayed or time-release formulations.

To ensure consistent product for pharmaceutical use it’s important to choose a highly reputable supplier of pharmaceutical excipients. Colorcon manufactures sugar spheres to comply with specifications as outlined in the current version of the USP/NF and PhEur and in compliance with applicable excipient GMP requirements based on the USP/NF General Chapter and Good Manufacturing Processes for Bulk Pharmaceutical. They also meet all specifications for sugar spheres as outlined in the current version of USP /NF, JPE and PhEur.

Product Literature