AFFINISOL™ Solubility Enhancing Polymers

Solving the Insoluble

AFFINISOL™ Hydroxypropyl Methylcellulose for Hot Melt Extrusion (HME)

Poor solubility of active pharmaceutical ingredients (API) is the leading challenge faced by the pharmaceutical industry. AFFINISOL™ polymers are uniquely tailored to address the solubilization requirement of these APIs.


AFFINISOL™ HPMC HME (hydroxypropyl methylcellulose) is designed for use in hot melt extrusion formulations, and used by pharmaceutical companies looking to enhance the solubilization and inhibit the recrystallization of APIs.

As a cellulosic polymer AFFINISOL™ HPMC HME maintains the familiar crystallization inhibiting properties of hypromellose, with the ability to be extruded over a wide temperature range, without the use of plasticizers. AFFINISOL™ HPMC HME simplifies formulation requirements, helps improve physical stability, and provides versatility in drug release profiles.

Applications for AFFINISOL™ Polymers

AFFINISOL™ polymers are uniquely tailored to address the solubilization performance requirements of your active APIs.

The use of HME is a growing formulation technology for pharmaceutical applications through it's ability to improve the solubility and prevent nucleation of poorly soluble drug compounds classified as Class II and Class IV under the Biopharmaceutics Classification System.

AFFINISOL™ is a trademark of International Flavors and Fragrances Inc. or its affiliates.  © 2021 IFF.  All rights reserved 

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