POLYOX™ Water-Soluble Resins for Pharmaceutical Applications
POLYOX™ Water-Soluble Resins (NF grades) are non-ionic poly (ethylene oxide) polymers. They are hydrophilic polymers available in a wide range of molecular weights and are supplied as white, free flowing powders. POLYOX™ offers a history of successful use in extended release applications, including osmotic pump technologies.
Other applications include hydrophilic matrices, gastro-retentive dosage forms, tamper-resistant technologies and other drug delivery systems such as transdermal and muco-adhesive technologies.
Product LiteratureProduct Application Data General Information Product Brochure Published Posters Published White Papers / Articles
Product Application Data
Antioxidant Use in POLYOX™ ER MatricesView and Download
Application of Opadry® II on metformin HCl ER matrices containing POLYOX™View and Download
Behavior of tablets containing POLYOX during coating, independent of a drug and other excipients
Dissolution Testing for POLYOX™ ER MatricesView and Download
Evaluation of Various Materials for Cleaning of Processing Area and Equipment after using POLYOX™View and Download
Formulation of POLYOX™ ER Matrices for a Highly Soluble ActiveView and Download
POLYOX polymers can be used as an alternative to HPMC in ER matrix tablets
Physico-mechanical Characterization of POLYOX™ for Tablet ManufactureView and Download
The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release MatricesView and Download
Techincal Bulletin: POLYOX™ FormulationView and Download
Introduction to formulation of Osmotic Push-Pull Technology using POLYOX
Technical Bulletin: POLYOX™ ManufacturingView and Download
Introduction to manufacturing and processing of Osmotic Pump technology using POLYOX
AAPS 2010 - Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide ER Matrix TabletsView and Download
Using model APIs robust POLYOX ER matrix tablets were produced - practically water insoluble
drug gliclazide and freely water soluble metformin HCl
AAPS 2011 - Effect of Film Coating on the Stability of ER Metformin Hydrochloride POLYOX™ MatricesView and Download
Application of PVA-based Opadry II results in enhanced tablet stability and prevented loss of mechanical strength during accelerated storage conditions
AAPS 2011 - Effect of Formulation and Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugView and Download
AAPS 2011 - Effect of Semipermeable Coating Composition and Opadry Top-Coating Systems on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugView and Download
Investigate the effect of the SPM coating, comprising cellulose acetate with different grades of polyethylene glycol(PEG)
AAPS 2011 - Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide and Hypromellose ER MatricesView and Download
Influence of ionic polymer NaCMC, on the release of model drug from ER formulations containing non-ionic polymers, PEO or HPMC, as matrix formers.
AAPS 2013 - Immediate Release Film Coating of an Acetaminophen Extended Release Matrix Tablet Containing a High Concentration of Polyethylene Oxide Water Soluble ResinView and Download
Investigation of film coating with Opadry II on hydrophilic matrix tablets
AAPS 2013 - Investigation of Direct Compression Processing of Push Layer System for Osmotic Pump TabletsView and Download
Direct Compression Processing of Push Layer System for Osmotic Pump Tablets
AAPS 2013 - Study of Dose-Weight Proportionality in Osmotic Push-Pull TechnologyView and Download
The purpose of this work was to formulate dose-weight proportional formulation of model drug (theophylline) at 10, 15 and 20 mg doses using standard round concave (SRC) tooling of proportional dimensions to achieve similar drug
release profiles. Surface area, volume and shape of the osmotic tablets were analyzed to further explore mechanism
of drug release.
AAPS 2015 - Eliminating Burst Release of Highly Soluble Drug from Hydrophilic Matrix Tablets Using Venlafaxine as a Model DrugView and Download
Combination of ionic low viscosity polymer with high viscosity Hypromellose reduced drug release within first 2 hours of dissolution.
APS 2010 - Influence of Polymer Concentration on Release of Poorly Soluble Drugs from Polyethylene Oxide ER MatricesView and Download
Reproducible zero and first order drug release profiles; solubility of the API and PEO concentration had an effect on drug release
CRS 2011 - Development of Push-Pull Osmotic Pump Tablets for a Slightly Water Soluble DrugView and Download
Irrespective of the multiple steps involved in manufacture, equivalent performance to commercial tablets with respect to physical properties, drug release and push-pull pattern was seen
CRS 2011 - Effect of Different Processing Conditions on the Performance of Push-Pull Osmotic Pump Tablets of a Slightly Water Soluble DrugView and Download
Effects of tablet mechanical strength, drying method of granules and methods of tablet manufacture (manual vs. rotary tablet press) on performance of PPOP tablets
CRS 2011 - The Influence of Sodium Carboxymethyl Cellulose on Drug Release from Polyethylene Oxide ER MatricesView and Download
Potential synergistic interaction can be used to design new oral ER pharmaceutical dosage forms with more
prolonged release, using lower polymer amounts
CRS 2012 - Effect of Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugView and Download
Fundamental understanding of the relationship between process variables and PPOP performance.
CRS 2012 - Influence of Cellulose Acetate Weight Gain and Solvent Ratio on Performance of Push-Pull Osmotic Pump TabletsView and Download
Effect of Opadry CA coating on the properties of push-pull osmotic pump (PPOP) tablets
CRS 2012 - Influence of Level and Location of NaCl on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugView and Download
Robustness of osmotic technology for zero order drug release and approaches to modulate drug release using the osmogen concentration and location
CRS 2012 - Investigation of Cellulose Acetate Polymer Viscosity and Coating Solution Concentration on Performance of Push-Pull Osmotic Pump (PPOP) TabletsView and Download
Critical material attributes and process parameters for consideration in development of osmotic pumps coated with Opaddry CA
CRS 2013 - Effect of Polyethylene Oxide Molecular Weight and Osmogen Content on Performance of Push-Pull Osmotic Pump TabletsView and Download
DOE determines osmogen level and interaction with POLYOX MW impacts drug release from PPOP
CRS 2014 - The Influence of Manufacturing Method on Physical Properties and Drug Release from Push-Pull Osmotic Pump (PPOP) ProductsView and Download
Evaluation of manufacturing methods and the impact on physical and chemical properties of granules, tablets and resulting drug release.
Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix TabletView and Download
The effect of various fillers on the oxidative stability of POLYOX in a matrix tablet
Published White Papers / Articles
Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide ER Matrix TabletsView and Download
Pharmaceutical Technology Europe - July 2011
POLYOX™ water-soluble resins provide a number of benefits including:
- Wide range of molecular weights for formulation flexibility
- Versatile application in direct compression and granulation
- Rapid hydration and swelling for use in osmotic pump technologies
- Fast hydration and gel formation for use in hydrophilic matrices
- Extreme hardness and virtually crush-proof for tamper-resistant technologies
Colorcon, through the Controlled Release Alliance, has exclusive, global sales and distribution rights for POLYOX™ products from IFF for use in controlled release applications.
POLYOX™ is a trademark of International Flavors and Fragrances Inc. or its affiliates.
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