METHOCEL™ Premium CR Cellulose Ethers
First choice for the formulation of hydrophilic matrix systems, providing a robust mechanism for the extended/controlled release of drugs from oral solid dosage forms. With a choice of viscosity grades METHOCEL™ premium cellulose ethers provide a simple solution to meet a range of drug solubility needs. Tablets are easily manufactured with existing, conventional equipment and processing methods.
Matrix Tablet Formulations
|Application||Benefits||Typically Used METHOCEL™ Cellulose Ethers|
|Low Solubility Drugs||Fast polymer hydration to form gel layer; non-ionic||E50LV, K100LV, K100LV CR|
|Med to High Solubility Drug||Fast polymer hydration to form gel layer; non-ionic||
K4M, K15M, K100M, E4M, E10M, K4MCR, K15MCR, K100MCR, E4MCR, E10MCR
Now available as directly compressible grades, METHOCEL™ DC2 polymers deliver exceptional flow properties and process capability as well as consistent modified release performance for matrix formulations. METHOCEL™ DC2 will enable manufacturers to replace costly wet granulation in matrix tablet production with cost effective dry granulation and direct compression techniques.
Three direct compression grades of METHOCEL™ DC2 are now available: K100 LV, K4M and K100M; chemically identical to current METHOCEL™ Premium products and meet USP, PhEur and JP specifications.
Colorcon, through the Controlled Release Alliance, has exclusive, global sales and distribution rights for METHOCEL™ products from IFF for use in controlled release applications.
METHOCEL™ is a trademark of International Flavors and Fragrances Inc. or its affiliates. © 2021 IFF. All rights reserved
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