METHOCEL™ Premium CR Cellulose Ethers
First choice for the formulation of hydrophilic matrix systems, providing a robust mechanism for the extended/controlled release of drugs from oral solid dosage forms. With a choice of viscosity grades METHOCEL™ premium cellulose ethers provide a simple solution to meet a range of drug solubility needs. Tablets are easily manufactured with existing, conventional equipment and processing methods.
Matrix Tablet Formulations
|Application||Benefits||Typically Used METHOCEL™ Cellulose Ethers|
|Low Solubility Drugs||Fast polymer hydration to form gel layer; non-ionic||E50LV, K100LV, K100LV CR|
|Med to High Solubility Drug||Fast polymer hydration to form gel layer; non-ionic||K4M, K15M, K100M, E4M, E10M, K4MCR, K15MCR, K100MCR, E4MCR, E10MCR|
Product LiteratureProduct Application Data General Information Product Brochure Published Posters Published White Papers / Articles
Product Application Data
Maintaining Similar Drug Release from Hypromellose Matrices with Identical Dimensions but Different Dose StrengthsView and Download
Method to maintain similar drug release, tablet shape and weight, from a METHOCEL matrix, while adjusting the drug dose.
Technical Bulletin: METHOCEL™ K200MView and Download
Introducing METHOCEL K200M for extended release formulation
Technical Bulletin:Film Coating of Hydrophilic MatricesView and Download
Film Coating of Hydrophilic Matrix Tablets : Safety Considerations for Product Design to Minimize Medication Errors
An Introduction to METHOCEL™ Premium Cellulose EthersView and Download
Blending METHOCEL™ for Intermediate ViscosityView and Download
General Properties of METHOCEL™ Premium Cellulose EthersView and Download
This product data sheet describes chemical and physical properties of METHOCEL premium cellulose ethers.
How to Prepare Aqueous Solutions of METHOCEL™View and Download
Describes preparation of aqueous solutions of METHOCEL.
How to Prepare Solutions of METHOCEL™ in Nonaqueous SolventsView and Download
Properties of Solutions of METHOCEL™View and Download
Quality by Design (QbD) for METHOCEL™ Premium CR Cellulose EthersView and Download
Introduction to QbD initiatives for the robust design of product and manufacturing process of hydrophilic matrices.
METHOCEL™ Product Information BrochureView and Download
Using METHOCEL™ Cellulose Ethers for Controlled Release of Drugs in Hydrophilic Matrix SystemsView and Download
AAPS 2005 - Investigation of a Directly Compressible Hypromellose Matrix Formulation for a Low Dose, Practically Insoluble DrugView and Download
Formulation of an ER direct compression Indapamide (1.5 mg) matrix tablet using METHOCEL
AAPS 2005 - Particle Swelling and Coalescence to Gel Layer FormationView and Download
Swelling and coalescence behavior of HPMC and Starch 1500, in order to monitor the contribution to gel layer formation in matrices.
AAPS 2006 - Evaluation of Verapamil HCl ER Matrix FormulationsView and Download
Investigating the use of dissolution testing apparatus III and biorelevant dissolution media to understand in vivo release of drug from hydrophilic matrices.
AAPS 2006 - Influence of Hydro-Alcoholic Media on Hypromellose Matrix SystemsView and Download
Effect of hydro-alcoholic dissolution media on the swelling and drug release properties of METHOCEL matrices.
AAPS 2006 - Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst EffectView and Download
Method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL matrices.
AAPS 2007 - Bi-Phasic Drug Release from Drug Layered, ER Hypromellose MatricesView and Download
Process to achieve an immediate and extended release profile from an HPMC matrix system.
AAPS 2007 - Influence of Anionic Polymers on Hydrochlorothiazide ER Hypromellose MatricesView and Download
Blending anionic polymers with HPMC to extend release; effects of varying polymer blend ratio and excipient choice - drug release profile and textural properties.
AAPS 2007 - Investigation of the Effects of Hydro-Alcoholic Media on Rheological and Textural Properties of Various Grades of HypromelloseView and Download
Effect of hydro-alcoholic dissolution media on the textural properties of METHOCEL matrices, and rheological properties of METHOCEL solutions.
AAPS 2008 - Influence of Hydrodynamic Conditions on Verapamil Hydrochloride Release from Hydrophilic Matrices Using Ionic and Non-Ionic PolymersView and Download
Combination of HPMC with ionic polymers in ER matrices, with a soluble API, provides robust formulations which are insensitive to hydrodynamic conditions.
AAPS 2010 - Application of QbD Principles to the Formulation of ER Propranolol Hydrochloride Hydrophilic Matrix TabletsView and Download
Effects of variation in hypromellose physico-chemical properties on powder flow, tablet physical properties and in vitro drug release profiles, from an ER hydrophilic matrix tablet using QbD principles.
AAPS 2010 - Effect of Filler Type on Low Dose Acetaminophen Hydrophilic Matrix FormulationsView and Download
Effect of four commonly used fillers in formulation and processing of HPMC matrices utilizing a high shear wet granulation process.
AAPS 2011 - Barrier Membrane Coating of Hydrophilic Matrices of Sparingly Soluble Drug, Acetaminophen: A Strategy to Reduce Possible Food EffectView and Download
Application of a barrier membrane (BM) coating consisting of Surelease and a pore-former, Opadry.
AAPS 2011 - Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide and Hypromellose ER MatricesView and Download
Influence of ionic polymer NaCMC, on the release of model drug from ER formulations containing non-ionic polymers, PEO or HPMC, as matrix formers.
AAPS 2012 - Barrier Membrane Coated Hydrophilic Matrices: Robustness of Metoprolol Tartrate Release under Biorelevant Test Conditions – Impact of Media CompositionView and Download
Joint poster - Ernst Moritz Arndt University & Colorcon
AAPS 2012 - Critical Material Attributes Consideration for ER Propranolol HCl Hydrophilic Matrix TabletsView and Download
Hypromellose CMA had no significant effect on the physical properties of ER matrix tablets, but may impact drug release profiles when level of METHOCEL is low (15% w/w).
AAPS 2012 - Stability of Ethylcellulose Barrier Membrane Coated Hydrochlorothiazide Matrices Comprising Starch 1500® or Lactose as FillerView and Download
Starch 1500 contributed to robustness of the barrier membrane coated matrix tablets.
AAPS 2013 - Investigation of Drug Release Performance of Hydrophilic Extended Release Formulations in Bio-Relevant MediaView and Download
Drug Release Performance of Hydrophilic ER Formulations in Bio-Relevant Media
AAPS 2014 - Study of Dose-proportionality in Hydrophilic Matrix Tablets using Propranolol HCl as a Model DrugView and Download
Study of the surface area to volume ratio (SA/V) of uncoated matrices analyzed to explore feasibility of getting similar release profiles at proportional weights of tablets.
AAPS 2015 - Eliminating Burst Release of Highly Soluble Drug from Hydrophilic Matrix Tablets Using Venlafaxine as a Model DrugView and Download
Combination of ionic low viscosity polymer with high viscosity Hypromellose reduced drug release within first 2 hours of dissolution.
CRS 2003 - The Influence of Film Coatings on Performance of Hypromellose MatricesView and Download
Study on the influence of three film coating systems on the performance of hypromellose sustained release matrices, stored under different conditions up to 12 months.
CRS 2005 - Direct Compression Metformin HCl ER Formula Based on HypromelloseView and Download
CRS 2005 - Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240mg) ER FormulationView and Download
Impact of the type of dissolution testing method on drug release.
CRS 2006 - Effect of Film Coating and Storage Conditions on the Performance of Metformin HCl 500 mg ER Hypromellose MatricesView and Download
Influence of three film coating systems on the performance of Metformin HCl (500mg) extended release (ER) Hypromellose matrices.
CRS 2006 - Influence of Formulation Variables on Drug Release Kinetics from Hypromellose ER MatricesView and Download
Mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL matrices.
CRS 2006 - Investigation of a Venlafaxine HCl ER Formulation using Hypromellose MatricesView and Download
Minimizing burst of drug release of highly soluble actives from METHOCEL matrices; granulation of the drug, and coating on top of the matrix, with Surelease
CRS 2008 - Use of Roller Compaction in the Preparation of Verapamil Hydrochloride ER Matrix Tablets Containing Hydrophilic PolymersView and Download
Evaluation of roller compaction on the flow and compressibility of blends of HPMC, polyvinyl acetate phthalate(PVAP) and carbomer - ER verapamil HCl matrix formulation.
CRS 2009 - Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl ER MatricesView and Download
Effects of processing on the properties of the polymer blend, tablets and drug release.
CRS 2009 - Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose MatricesView and Download
Different tablet shapes to evaluate the effect of geometry on the release of model drugs, with varying aqueous solubility and dose, from hydrophilic matrices at constant tablet surface area/volume ratios.
CRS 2010 - Effect of Processing Conditions on Hypromellose Matrix Formulations of Acetaminophen Prepared by a High Shear Wet Granulation ProcessView and Download
Processing guidelines for developing a hypromellose matrix formulation using a wet granulation process; with extra-granular addition of HPMC and Starch 1500 resulting in increased tablet hardness.
CRS 2010 - Utility of Ultra-High Viscosity Hypromellose in ER Matrix FormulationsView and Download
Showing that the use of ultra-high viscosity BENECEL K200M in an ER matrix system did not show any advantage in drug release retardation compared to METHOCEL K100M.
CRS 2011 - Application of QbD Principles to the Formulation of ER Theophylline Hydrophilic Matrix TabletsView and Download
Ranges of viscosity, % HP and particle size of METHOCEL™ K15M Premium CR had no significant effect on physical properties of power blends, tablet physical properties and drug release profiles.
CRS 2011 - Use of Starch 1500® to Minimize Variability on Drug Release from Hypromellose MatricesView and Download
Starch 1500 in formulation design, supporting QbD study and minimizing formulation variability
CRS 2012 - Barrier Membrane Coating of Hydrophilic Matrices of a Very Soluble Drug, Metoprolol Tartrate at High Dose: A Strategy to Eliminate the Initial Burst ReleaseView and Download
Application of barrier membrane (BM) coating, using Surelease with a pore-former, Opadry; elimination of the burst effect, followed by near zero order release.
CRS 2013 - Barrier Membrane Coating of Hydrophilic Matrices: A Simplified Strategy to Attain Zero Order Drug ReleaseView and Download
Alternative formulation strategy for dosage forms where zero order release of drug is desired
CRS 2013 - Consideration of Critical Material Attributes in Hypromellose-Based Hydrophilic Matrices Comprising Drugs of Various SolubilityView and Download
Case studies using theophylline (water solubility 8.3 mg/ml) or HCTZ (water solubility ~0.7 mg/ml) with METHOCEL K4M and Starch 1500 as the matrix former
CRS 2017 - Approaches to Reduce the Weight of Extended Release Tablets: Metformin HClView and Download
CRS 2017 - Study of Dose-Weight Proportionality of IR/SR Fixed Dose CombinationView and Download
CRS 2018 - Application of Barrier Membrane Coating to Reduce the Weight of Metformin HCI Extended Release TabletsView and Download
CRS 2020 - Effect of Different Fillers on Low Dose Extended Release Hydrophilic Matrix TabletsView and Download
CRS 2020 Poster Reprint
Published White Papers / Articles
Applications of Complementary Polymers in HPMC Hydrophilic Extended Release MatricesView and Download
Drug Delivery Technology - July/Aug 2009
Excipient Update: Influence of fillers, compression force, film coating, and storage conditions on performance of hypromellose matricesView and Download
Drug Delivery Technology - Jan/Feb 2004
Influence of Excipients on Drug Release from Hydroxypropyl Methylcellulose MatricesView and Download
JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 93, NO. 11, Nov 2004
Investigation of the Influence of Tablet Shape, Geometry & Film Coating on Drug Release From Hypromellose Extended-Release MatricesView and Download
Drug Delivery Technology article published March 2010.
Colorcon, through the Controlled Release Alliance, has exclusive, global sales and distribution rights for METHOCEL™ products from IFF for use in controlled release applications.
METHOCEL™ is a trademark of International Flavors and Fragrances Inc. or its affiliates.
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