ETHOCEL™ Premium Ethylcellulose Polymers
ETHOCEL™ products are water-insoluble polymers approved for global pharmaceutical applications and used in extended release solid dosage formulations.
Main pharmaceutical applications:
- Extended release multiparticulate coating
- Micro-encapsulation of actives
- Taste-masking of bitter actives
- Extended release binder in inert matrix systems
- Solvent and extrusion granulation
ETHOCEL™ provides formulation flexibility for pharmaceutical applications:
- Range of molecular weights, can be blended for intermediate viscosities
- Fine particle (FP) range for use in inert matrix systems, providing improved lipophilic properties realized by increase in surface area
- Modify release profiles when ETHOCEL™ is used in combination with water-soluble excipients, such as METHOCEL™ premium cellulose ethers
ETHOCEL™ has been widely used in the Pharmaceutical industry for over 50 years, backed by an excellent safety record with global compendial acceptance and compliance with the US Food Chemical Codex. Also approved for dietary supplement use in Europe and USA.ETHOCEL™ is a trademark of International Flavors and Fragrances Inc. or its affiliates. © 2021 IFF. All rights reserved
AAPS 2008 - Investigation of Ethylcellulose in the Preparation of Theophylline ER Inert Matrix TabletsView and Download
Influence of particle size and mol. wt.of ethylcellulose on drug release from inert matrices, with sparingly water soluble drug
AAPS 2012 - Stability of Ethylcellulose Barrier Membrane Coated Hydrochlorothiazide Matrices Comprising Starch 1500® or Lactose as FillerView and Download
Starch 1500 contributed to robustness of the barrier membrane coated matrix tablets.
AAPS 2014 - A QbD Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate Extended Release MultiparticulatesView and Download
Study showing that viscosity variation, within the manufacturer’s specifications for ETHOCEL Premium grades, has minimal impact on drug release for extended release multiparticulates.
AAPS 2015 - Feasibility of Taste-Masking a Highly Soluble Drug via Powder Layering with Fine Particle EthylcelluloseView and Download
AAPS 2015 Poster Reprint - Demonstrates the feasibility of ETHOCEL FP powder layering, onto drug loaded Suglets, as a highly efficient taste-masking technology.
AAPS 2017 - Stability Evaluation of Ethylcellulose Dry Powder Coated Metoprolol Tartrate Extended Release MultiparticulatesView and Download
CRS 2008 - Influence of Solvent Type on ER Coating with Ethylcellulose Barrier MembranesView and Download
Influence of solvent combinations on EC solution viscosity and drug release from coated beads
CRS 2008 - Investigation of Venlafaxine HCl Release from Extruded and Spheronized Beads Coated with Ethylcellulose using Organic or Aqueous Coating SystemsView and Download
Organic application of EC on venlafaxine HCl extruded and
spheronized beads resulted in a consistent drug release
CRS 2009 - Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated MultiparticulatesView and Download
ADS adapted from 2009 CRS poster,The Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated Multiparticulates
CRS 2009 - Influence of Molecular Weight on Drug Release from Ethylcellulose Barrier Membrane MultiparticulatesView and Download
Drug release is retarded with increasing molecular weight (viscosity) of EC
CRS 2010 - Influence of Pore-Former on Drug Release from Ethylcellulose Coated MultiparticulatesView and Download
Multiparticulate beads coated with ethylcellulose from an organic solution
CRS 2011 - Influence of Dissolution Media pH on Drug Release from Ethylcellulose Coated MultiparticulatesView and Download
Comparative evaluation in gastric and intestinal pH media for ionic or non-ionic drugs
CRS 2011 - Influence of Drug Solubility on Release from Ethylcellulose Barrier Membrane Coated MultiparticulatesView and Download
Solvent coateding lead to slower drug release than when coated with aqueous dispersion and drug release rate increased with addition of hypromellose as a pore-former
CRS 2014 - Investigation of the Effect of Ethylcellulose Viscosity Variation Using QbD Samples on Drug Release from Extended Release MultiparticulatesView and Download
Effect of viscosity variation for ETHOCEL™ QbD samples (Std. 10, 20 and 100 Premium grades) coated onto drug layered multiparticlates.