Opadry® II High Performance Film Coating System

Effect of Coating Process Conditions and Coating Formula Type on the Quantity and Location of Water in Film Coated Tablets

Study of process conditions and formula type on tablet moisture gain.

Modern Tablet Film Coatings and Influence on Ease of Swallowing

This Application Data Sheet is extracted from a study of esophageal transit times using uncoated and film-coated caplets,oval tablets, plus hard and soft-gelatin capsules. Reprint of poster presented at the American Association of Pharmaceutical Scientists Meeting, 2003.

Opadry® II Coating Parameters - Clear (PVA-based) Formulations

Starting process recommendations for use of Opadry II, clear formulations.

Opadry® II Coating Parameters - Pigmented (PVA-based) Formulations

Starting process recommendations for Opadry II pigmented formulations.

AAPS 2003 - Modern Tablet Film Coatings and Influence on Ease of Swallowing

The objective of this study was to investigate if film coated tablets have shorter mean esophageal transit times and lower incidences of transit delays than those of uncoated tablets, or comparably sized hard or soft gelatin capsules.

AAPS 2005 - Evaluation of a Film Coating that Produces Enhanced Tablet-to-Tablet Film Uniformity

In this study, Opadry II (85 series) Clear was shown to have lower coating weight gain standard deviations than a standard clear hypromellose based film coating. Pigmented Opadry II (85 series) achieved similar or better coating color uniformity with a 1/3 savings in processing time.

AAPS 2005 - Investigation into the Flow Properties of Coated and Uncoated Tablets and Its Relevance to Blister Packing Efficiency

Study on reducing contamination and improving packaging line efficiency through the application of a fully formulated film coating.

AAPS 2006 - Protection and Processing of a Highly Hygroscopic Herbal Extract by Drug Layering and Film Coating

Study of the stability improvements for Echinacea Purpurea beads layered with a moisture PVA and HPMC based barrier film coating.

AAPS 2007 - Reducing Coated Tablet Defects from Laboratory Through Production Scale: Performance of Hypromellose Based and Polyvinyl Alcohol Based Aqueous Film Coating Systems

The purpose of this study was to examine the effect of film coating formulations in reducing or preventing coating defects on a soft and friable multivitamin tablet.

AAPS 2008 - Evaluation of Recent Advances in Continuous Film Coating Technology in Reducing or Eliminating Potential Product Losses

This study evaluates the performance of Opadry II in a continuous coating process and demonstrates that improvements in continuous coater designs have reduced the need for re-work or discarding of partially coated product.

AAPS 2008 - Scuffing Measurement Methodology and Improved Film Coating Systems

This study describes laboratory tests to measure scuffing on film coated tablets and provides process and maintenance recommendations to prevent the occurrence of scuffing.

AAPS 2009 - Determination of Trace Formic Acid and Formaldehyde in Film Coatings Comprising Polyvinyl Alcohol (PVA)

This work describes the application of a methodology developed by Amgen to determine the amounts of formic acid and formaldehyde in PVA-based film coatings.

AAPS 2009 - Film Coating Process Considerations for the Application of High Productivity, High Solids Concentration Film Coating Formulations

Using a Design of Experiments (DOE) approach, this study examines the effect of solids concentration on color uniformity and coating weight variation (CWV) in a batch coating process.

AAPS 2009 - Influence of Film Coating Process Parameters on the Gloss of Tablets Coated with Pigmented Aqueous Film Coating Formulations

The purpose of this study was to examine the effects of coating process parameters and dispersion solids concentration on the gloss of tablets coated with single-step, pigmented aqueous film coating formulations.

AAPS 2009 - Maximizing the Gloss of PVA-Based Film Coating Systems

Results of this study reveal gloss level improvements when PVA-based pigmented film coatings are applied at lower solids content levels.

AAPS 2009 - Use of Maximum Fluid Delivery Rate Measurements to Assess the Productivity of Moisture Barrier Film Coatings

The aim of this study was to develop a small-scale method predicting film coating productivity of moisutre barrier film coatings. Maximum fluid delivery rates were used to evaluate the productivity and inherent tack of formulations, Opadry II, Opadry amb and a developmental formulation.

AAPS 2010 - Stability of Six Model Drug Products Coated with PVA-based Opadry® II

The purpose of this study was to investigate the influence of PVA-based OpadryII systems on stability and release of immediate release formulations containing six model drugs, after storage at accelerated conditions.

AAPS 2011 - Effect of Film Coating on the Stability of ER Metformin Hydrochloride POLYOX™ Matrices

Application of PVA-based Opadry II results in enhanced tablet stability and prevented loss of mechanical strength during accelerated storage conditions

AAPS 2013 - Immediate Release Film Coating of an Acetaminophen Extended Release Matrix Tablet Containing a High Concentration of Polyethylene Oxide Water Soluble Resin

Investigation of film coating with Opadry II on hydrophilic matrix tablets

AAPS 2017 On-Demand Film Coating Dispersion Preparation

AAPS 2020 - Evaluation of Different Opadry® Film Coating Systems on Tablets Containing Amorphous Solid Dispersion of Itraconazole

AAPS 2021 - Performance and Stability of an On-Dosage Authentication Technology Using Molecular Tags on the Coated a Model Active

CRS 2003 - The Influence of Film Coatings on Performance of Hypromellose Matrices

Study on the influence of three film coating systems on the performance of hypromellose sustained release matrices, stored under different conditions up to 12 months.

CRS 2006 - Effect of Film Coating and Storage Conditions on the Performance of Metformin HCl 500 mg ER Hypromellose Matrices

Influence of three film coating systems on the performance of Metformin HCl (500mg) extended release (ER) Hypromellose matrices.

SAFYBI 2005 - Coating Moisture-Sensitive Products with Opadry® II

Influence of inlet temperature and airflow on moisture uptake by tablet cores using a PVA-based film coating system.

Dare to be Different - Use Color and Shape for Unique Tablet Design

This article is from Medicine Maker, March 2015 issue.

Film Coating for Pediatric Oral Solid Dosage Forms

Getting the Right Coating for Pediatric Tablet Formulations