POLYOX™ Water-Soluble Resins for Pharmaceutical Applications
POLYOX™ Water-Soluble Resins (NF grades) are non-ionic poly (ethylene oxide) polymers. They are hydrophilic polymers available in a wide range of molecular weights and are supplied as white, free flowing powders. POLYOX™ offers a history of successful use in extended release applications, including osmotic pump technologies.
Other applications include hydrophilic matrices, gastro-retentive dosage forms, tamper-resistant technologies and other drug delivery systems such as transdermal and muco-adhesive technologies.
Product LiteratureProduct Application Data General Information Product Brochure Published Posters Published White Papers / Articles
Product Application Data
AAPS 2011 - Effect of Semipermeable Coating Composition and Opadry Top-Coating Systems on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugView and Download Send by Email
Investigate the effect of the SPM coating, comprising cellulose acetate with different grades of polyethylene glycol(PEG)
AAPS 2011 - Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide and Hypromellose ER MatricesView and Download Send by Email
Influence of ionic polymer NaCMC, on the release of model drug from ER formulations containing non-ionic polymers, PEO or HPMC, as matrix formers.
AAPS 2013 - Study of Dose-Weight Proportionality in Osmotic Push-Pull TechnologyView and Download Send by Email
The purpose of this work was to formulate dose-weight proportional formulation of model drug (theophylline) at 10, 15 and 20 mg doses using standard round concave (SRC) tooling of proportional dimensions to achieve similar drug
release profiles. Surface area, volume and shape of the osmotic tablets were analyzed to further explore mechanism
of drug release.
CRS 2011 - Development of Push-Pull Osmotic Pump Tablets for a Slightly Water Soluble DrugView and Download Send by Email
Irrespective of the multiple steps involved in manufacture, equivalent performance to commercial tablets with respect to physical properties, drug release and push-pull pattern was seen
CRS 2011 - Effect of Different Processing Conditions on the Performance of Push-Pull Osmotic Pump Tablets of a Slightly Water Soluble DrugView and Download Send by Email
Effects of tablet mechanical strength, drying method of granules and methods of tablet manufacture (manual vs. rotary tablet press) on performance of PPOP tablets
CRS 2012 - Influence of Level and Location of NaCl on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugView and Download Send by Email
Robustness of osmotic technology for zero order drug release and approaches to modulate drug release using the osmogen concentration and location
CRS 2012 - Investigation of Cellulose Acetate Polymer Viscosity and Coating Solution Concentration on Performance of Push-Pull Osmotic Pump (PPOP) TabletsView and Download Send by Email
Critical material attributes and process parameters for consideration in development of osmotic pumps coated with Opaddry CA
CRS 2014 - The Influence of Manufacturing Method on Physical Properties and Drug Release from Push-Pull Osmotic Pump (PPOP) ProductsView and Download Send by Email
Evaluation of manufacturing methods and the impact on physical and chemical properties of granules, tablets and resulting drug release.
Published White Papers / Articles
POLYOX™ water-soluble resins provide a number of benefits including:
- Wide range of molecular weights for formulation flexibility
- Versatile application in direct compression and granulation
- Rapid hydration and swelling for use in osmotic pump technologies
- Fast hydration and gel formation for use in hydrophilic matrices
- Extreme hardness and virtually crush-proof for tamper-resistant technologies
Colorcon, through the Controlled Release Alliance, has exclusive, global sales and distribution rights for POLYOX™ products from IFF for use in controlled release applications.
POLYOX™ is a trademark of International Flavors and Fragrances Inc. or its affiliates.
© 2021 IFF. All rights reserved
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