アクリーズ™ 水系アクリル腸溶性システム
アクリーズ™、水系腸溶性システムは完全処方化高性能コーティングシステムです。プロトンポンプ阻害剤(PPI)アプリケーションを含む、錠剤または多粒子経口固形製剤用としてデザインされています。
目標耐酸性PH値 アプリケーション
アクリーズは、プレミックス処方のため開発と製造で大幅な時間の節約となります。酸性条件で保護し、小腸液条件で速やかに薬物を放出します..可塑剤は後から選択して添加することが可能です。
アクリーズIIは、中間PH範囲での耐酸性を向上した高性能コーティングです。プロトンポンプ阻害剤（PPI）アプリケーションに適しており、アクリーズシステムと比較してより低いコーティング量で腸溶性が達成できます。
開発と製造時間の節約
- 完全処方化システム
- コーティング分散液の調製が簡便（20分）、洗浄が簡単
- 原材料在庫とQC要件の削減
アプリケーションの柔軟性
- 錠剤、顆粒、多粒子での使用に適切
- in vivo 試験で性能確認済み
一般的な情報
Acryl-EZE® 93A Product Information
ドキュメントのダウンロード 電子メールで送信93A series key characteristics, applications, packaging, storage and reevaluation information.
Acryl-EZE® Enteric Coating Stability
ドキュメントのダウンロード 電子メールで送信Stability information for Acryl-EZE coated, delayed release aspirin tablets, at ambient and accelerated storage conditions.
Acryl-EZE® MP Product Information
ドキュメントのダウンロード 電子メールで送信Acryl-EZE MP series key characteristics, applications, packaging, storage and reevaluation information.
Acryl-EZE® Product Stability
ドキュメントのダウンロード 電子メールで送信Stability information for reconstituted Acryl-EZE powder formulations at ambient and accelerated storage conditions.
製品のプロセスパラメーター
Acryl-EZE® Coating Parameters
ドキュメントのダウンロード 電子メールで送信Recommended coating process parameters for Acryl-EZE in laboratory, pilot, and production scale coating pans.
Acryl-EZE® II Coating Parameters – Multiparticulate Applications
ドキュメントのダウンロード 電子メールで送信Recommended coating process parameters for Acryl-EZE II on Multiparticulates
Acryl-EZE® II Coating Parameters – Tablet Applications
ドキュメントのダウンロード 電子メールで送信Recommended coating process parameters for Acryl-EZE II on Tablets
Acryl-EZE® MP Coating Parameters
ドキュメントのダウンロード 電子メールで送信Recommended coating process parameters for Acryl-EZE MP in laboratory and pilot scale fluid bed coaters.
調製方法
Acryl-EZE® 93A Preparation and Use Sheet
ドキュメントのダウンロード 電子メールで送信Recommended dispersion mixing procedures, coating levels, and cleaning guidelines.
Acryl-EZE® II Preparation and Use Sheet
ドキュメントのダウンロード 電子メールで送信Outline of the recommended dispersion mixing procedures for tablets or multiparticulates including coating levels, and cleaning guidelines
Acryl-EZE® MP Preparation and Use Sheet
ドキュメントのダウンロード 電子メールで送信Outline of the recommended dispersion mixing procedures, coating levels, and cleaning guidelines for Acryl-EZE MP.
Acryl-EZE® Preparation and Use Sheet
ドキュメントのダウンロード 電子メールで送信Outline of the recommended dispersion mixing procedures, coating levels, and cleaning guidelines.
製品カタログ
Acryl-EZE® Product Information Brochure
ドキュメントのダウンロード 電子メールで送信Introduction to the Acryl-EZE platform of delayed release coating systems.
ポスター
AAPS 2000 - Acryl-EZE® Optimal Coating Parameters
ドキュメントのダウンロード 電子メールで送信Development of the optimum coating process parameters for Acryl-EZE dispersions.
AAPS 2001 - Preparation of an Enteric Dosage Form with a Water-Dispersible Acrylic Film Coating Formulation
ドキュメントのダウンロード 電子メールで送信Stability information for the Acryl-EZE® formulation including application to enteric-coated aspirin tablets.
AAPS 2001 - Production-Scale Process and Performance Comparison of Two Fully-Formulated Aqueous Enteric Coating Systems
ドキュメントのダウンロード 電子メールで送信Summary of the production scale evaluation of Acryl-EZE® and Sureteric® for coating process, enteric protection, and finished product stability.
AAPS 2002 - Preparation of Robust, Enteric-Coated Dosage Forms
ドキュメントのダウンロード 電子メールで送信Solutions for the application of aluminum lake pigmented Acryl-EZE formulations onto various actives, to provide stable, reproducible drug release.
AAPS 2005 - Investigation of a Modified USP Disintegration Test Method for Enteric Coated Tablets
ドキュメントのダウンロード 電子メールで送信Outline of the method and rationale for the analysis of enteric-coated dosage forms in intermediate acidic pH conditions (pH 4.5).
AAPS 2005 - New Coating Process for the Application of Enteric Coatings to Small Tablet Samples
ドキュメントのダウンロード 電子メールで送信Investigation of a rapid application of an aqueous enteric coating system onto very small batch sizes of tablets using a novel coating process technology, the SUPERCELL™ process from Niro.
AAPS 2005 - The Effect of Superdisintegrant on Acid Resistance of Enteric Coated Tablets
ドキュメントのダウンロード 電子メールで送信Investigation of the influence of superdisintegrant type and level on the performance of two enteric coated tablet formulations.
AAPS 2005 - The Influence of Gastric Media (In-Vitro) on the Performance of Delayed Release Proton Pump Inhibitor Dosage Forms
ドキュメントのダウンロード 電子メールで送信Invstigation of the enteric performance of aqueous enteric-coated tablet formulations containing proton pump inhibitors (PPI’s) in bio-relevant media, better simulating the gastric environment of a patient on a multiple dose regimen of PPI’s.
AAPS 2006 - Application of Powder Layering Technology and Aqueous Enteric Coating
ドキュメントのダウンロード 電子メールで送信Study of Acryl-EZE 93 series when applied onto dry powder layered lansoprazole multiparticulates.
AAPS 2006 - Aqueous Enteric Coating Application on Non-Banded Hard Gelatin Capsules
ドキュメントのダウンロード 電子メールで送信Investigation of the delayed release performance of 93 series, when applied onto omeprazole filled, hard gelatin capsules.
AAPS 2008 - Evaluation of the Enteric Performance of Lansoprazole Mini-Tabs Coated in a Perforated Pan
ドキュメントのダウンロード 電子メールで送信The focus of this study was to investigate the potential of successful manufacture and enteric coating of lansoprazole mini-tabs using methacrylic acid co-polymers in a perforated pan. Along with other findings, this study will show that the mechanical strength of the mini-tabs significantly improved upon application of a seal-coat.
AAPS 2008 - Formulation and Process Considerations for Delayed Release Multi-Particulates of Esomeprazole Magnesium
ドキュメントのダウンロード 電子メールで送信Study of the application process for an enteric coating systemon an esomeprazole magnesium trihydrate (40 mg) multi-particulate system.
AAPS 2009 - The Influence of In Vitro Dissolution Method on Lansoprazole Release from Enteric Coated Mini-Tabs
ドキュメントのダウンロード 電子メールで送信Study of the Influence of In Vitro Dissolution Method on Lansoprazole Release from Enteric Coated Mini-Tabs
AAPS 2010 - Effects of Core Tablet Size on the Functionality of Aqueous Delayed Release Coatings as Measured by SEM and LIBS
ドキュメントのダウンロード 電子メールで送信The aim of this work was to develop a correlation between tablet surface area (size) and the minimum amount of coating weight gain/thickness of a functional coating necessary for enteric protection of tablets. The film coat thickness was determined via scanning electron microscopy (SEM) and laser-induced breakdown spectroscopy (LIBS).Acryl-EZE 93O formulations
AAPS 2013 - Investigaton of a New Semi-continuous Coating Process Using a Fully Formlated Enteric Coating System
ドキュメントのダウンロード 電子メールで送信Examining the suitability of the Omega novel semi-continuous coating process with a model Acryl-EZE enteric release coating system.
AAPS 2021 - Investigation of a Directly Compressible Pantoprazole Sodium Delayed Release Formulation ja
ドキュメントのダウンロード 電子メールで送信CRS 2001 - Performance Characteristics of Acryl-EZE®
ドキュメントのダウンロード 電子メールで送信Comparison of the performance of the Acryl-EZE fully formulated system versus a multiple step dispersion preparation of Eudragit L100-55.
CRS 2003 - Preparation of Stable, Gastro-Resistant Diclofenac Sodium Tablets, Utilizing Optimized Film-Coating Combinations
ドキュメントのダウンロード 電子メールで送信Demonstration of how to reduce overall coating process time and achieve drug product stability, by incorporating pigments directly into the Acryl-EZE enteric film layer.
CRS 2004 - Enteric Coating of Tablets with Debossed Logos
ドキュメントのダウンロード 電子メールで送信This ADS was adapated from the 2004 CRS poster demonstrating how to successfully enteric coat tablets which contain a debossed logo.
CRS 2006 - Controlled Permeability Films for Programmable Drug Release
ドキュメントのダウンロード 電子メールで送信Investigation of the influence of sodium alginate or hypromellose (HPMC) as pore formers in a delayed release film coating to achieve modified enteric drug release.
CRS 2006 - In-vitro Dissolution Testing of Delayed Release Multi-Particulate Systems
ドキュメントのダウンロード 電子メールで送信This poster study was to investigate the use of fumed silica as an anti-adherent agent to prevent potential agglomeration of multi-particulates in acid media.
CRS 2007 - The Influence of Plasticizer Type and Concentration on Acid Resistance of Coated Tablets
ドキュメントのダウンロード 電子メールで送信Investigation of the influence of plasticizer type and concentration on acid resistance, when added to Acryl-EZE® 93A, aqueous delayed-release (DR) film coating systems.
CRS 2008 - Investigation of Enteric Coating of Min-tabs Using a Perforated Pan or a Fluid-bed Machine
ドキュメントのダウンロード 電子メールで送信Feasibility study of using a perforated coating pan evaluated and compared to a fluid-bed machine. Differences between the two processes, in terms of coated tablet appearance, physical properties and enteric protection were studied.
