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- Surelease®
シュアリース™ エチルセルロース分散液 Type B NF
シュアリースは、持続性放出、完全水系コーティングシステムで、薬物放出の速度制御ポリマーとしてエチルセルロースを使用しています。この分散液はフィルム形成ポリマー、可塑剤と安定化剤のユニークな混合物で、持続性放出と味マスキングに使用できます。この確立された技術は、実験室からパイロットおよび生産スケールの工程まで一貫した、信頼性と再現性のある放出プロファイルを提供しています。
- 薬物放出は、シュアリース半透膜中の拡散が主
- 使用するシュアリースの量（フィルムの厚さ）を単純に増加または減少することにより、薬物放出速度を調節可能
- pHに依存しない一定の薬物放出性
- 味マスキングに使用
放出プロファイルを簡単に調節できるため、開発と生産の両方の時間を大いに節約できます。さらに、工程を最適化することによりコーティングの膜形成を確実にできるので、キュアリング工程をなくすことができます。シュアリースはまた、主要な薬局方の要件を満たした成分からなり、シュアリースを使用した製品は、世界中で承認されているので安全です。
一般的な情報
Surelease® Product Information
ドキュメントのダウンロード 電子メールで送信Overview of Surelease Ethylcellulose Dispersion Type B NF, including key characteristics, packaging and stability.
Tech Bulletin: Introducing Surelease® | Opadry® for Taste-Masking
ドキュメントのダウンロード 電子メールで送信Introduction to Taste-Masking with Surelease and Opadry
Tech Bulletin: Surelease® | Opadry® for Taste-Masking 2
ドキュメントのダウンロード 電子メールで送信Taste-masking with Surelease® and Opadry: Impact of Substrate Morphology
製品カタログ
Surelease® Product Information Brochure
ドキュメントのダウンロード 電子メールで送信Introduction to the Surelease platform of aqueous ethylcellulose dispersions.
ポスター
AAPS 2004 - Comparative Study of Theoretical Versus Actual Weight Gain for a Surelease® Barrier Membrane on Coated Pellets
ドキュメントのダウンロード 電子メールで送信This poster reprint outlines an analytical method to determine the quantity of ethylcellulose applied during coating, on multiparticulates.
AAPS 2006 - Hypromellose as a Pore Former in Aqueous Ethylcellulose Dispersion: Stability and Film Properties
ドキュメントのダウンロード 電子メールで送信Effect of HPMC as a pore-former on: stability of Surelease; quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
AAPS 2006 - Influence of Plasticizer Type on the Film Properties of a Fully-Formulated Aqueous Ethylcellulose Dispersion
ドキュメントのダウンロード 電子メールで送信AAPS 2006 - Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst Effect
ドキュメントのダウンロード 電子メールで送信Method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL matrices.
AAPS 2007 - Identification and Influence of Critical Coating Process Parameters on Drug Release from a Fully Formulated Aqueous Ethylcellulose Dispersion
ドキュメントのダウンロード 電子メールで送信Identify and study the influence of critical film coating process parameters for Surelease, on drug release behavior and process response variables.
AAPS 2007 - Influence of Hydrophilic Pore-Formers on Dipyridamole Release from Aqueous Ethylcellulose Film-Coated Pellets
ドキュメントのダウンロード 電子メールで送信Effect of incorporating water-soluble polyvinyl alcohol (PVA) and polyethylene glycol (PEG) as a pore former into Surelease films, and influence on drug release.
AAPS 2008 - Application of Surelease® in Preparation of Theophylline Extended Release Inert Matrix Tablets by Spray Granulation
ドキュメントのダウンロード 電子メールで送信Surelease Application Data document
AAPS 2008 - Influence of Post Coating Thermal Treatment on Film Properties and Drug Release from Ethylcellulose Barrier Membrane Coating Systems
ドキュメントのダウンロード 電子メールで送信Post coating treatment can affect both physico-mechanical properties of EC films and drug release from EC-coated multi-particulates.
AAPS 2011 - Barrier Membrane Coating of Hydrophilic Matrices of Sparingly Soluble Drug, Acetaminophen: A Strategy to Reduce Possible Food Effect
ドキュメントのダウンロード 電子メールで送信Application of a barrier membrane (BM) coating consisting of Surelease and a pore-former, Opadry.
AAPS 2012 - Barrier Membrane Coated Hydrophilic Matrices: Robustness of Metoprolol Tartrate Release under Biorelevant Test Conditions – Impact of Media Composition
ドキュメントのダウンロード 電子メールで送信Joint poster - Ernst Moritz Arndt University & Colorcon
AAPS 2012 - Barrier Membrane Coated Hydrophilic Matrices: Robustness of Metoprolol Tartrate Release under Biorelevant Test Conditions – Impact of pH and Mechanical Stress
ドキュメントのダウンロード 電子メールで送信Joint poster - Ernst Moritz Arndt University & Colorcon.
AAPS 2012 - Stability of Ethylcellulose Barrier Membrane Coated Hydrochlorothiazide Matrices Comprising Starch 1500® or Lactose as Filler
ドキュメントのダウンロード 電子メールで送信Starch 1500 contributed to robustness of the barrier membrane coated matrix tablets.
AAPS 2013 - Investigation of Taste Masking Performance of an Aqueous Ethylcellulose Dispersion
ドキュメントのダウンロード 電子メールで送信Evaluating the use of Surelease on taste masking of acetaminophen immediate release granules.
AAPS 2014 - A QbD Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate Extended Release Multiparticulates
ドキュメントのダウンロード 電子メールで送信Study showing that viscosity variation, within the manufacturer’s specifications for ETHOCEL Premium grades, has minimal impact on drug release for extended release multiparticulates.
AAPS 2014 - Fluid Bed Nozzle Spray Characterization of an Aqueous Ethylcellulose Dispersion for Particle Taste Masking Applications
ドキュメントのダウンロード 電子メールで送信Data from this study can be utilized to determine optimal spray conditions for the taste-masking of particles of various sizes in a fluid-bed coater at both laboratory and production scale.
AAPS 2016 - Effect of Surelease® Coating Conditions and Seal-coat on a Highly Soluble, Cationic Drug
ドキュメントのダウンロード 電子メールで送信Production of a sustained drug release multiparticulate dosage form showed no slowdown in dissolution even with cold and wet process conditions. Seal coating the beads after drug layering essentially eliminated the need to cure.
AAPS 2016 - Use of Raman Microscopy to Visualize the Integrity of a Barrier Membrane Coating for Taste-Masking of Acetaminophen Granules in Chewable Tablets
ドキュメントのダウンロード 電子メールで送信Study of the effect of substrate morphology and particle characteristics in maintaining the integrity of coating throughout the process of chewable tablet manufacture.
AAPS 2021 - Drug Release Stability of Propranolol Hydrochloride ER Multiparticulates using Ethylcellulose Dispersions ja
ドキュメントのダウンロード 電子メールで送信CRS 2005 - Evaluation of Alternative Plasticizers for Surelease® for Modified Release Film-Coating
ドキュメントのダウンロード 電子メールで送信Effects of various plasticizers on the thermal and physical properties of ethylcellulose.
CRS 2005 - Predictability of Drug Release from Multiparticulate Systems Coated with an Aqueous Ethylcellulose Dispersion
ドキュメントのダウンロード 電子メールで送信Drug release from drug layered beads varying in substrate size, and Surelease coating level.
CRS 2006 - Effect of Hypromellose as a Pore-Former in Aqueous Ethylcellulose Dispersion: Characterization of Dispersion Properties
ドキュメントのダウンロード 電子メールで送信Interactions between the HPMC and Surelease EC dispersion.
CRS 2007 - Application of an Aqueous Ethylcellulose Dispersion in Multiple-Unit Pellet Systems
ドキュメントのダウンロード 電子メールで送信Investigate drug release from compressed multiple-unit pellet systems, coated with Surelease
CRS 2007 - Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Non-Pareil Beads
ドキュメントのダウンロード 電子メールで送信CRS 2007 - Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose Coating
ドキュメントのダウンロード 電子メールで送信Effect of pore-former on the drug release of various actives from drug layered beads coated with Surelease.
CRS 2009 - Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated Multiparticulates
ドキュメントのダウンロード 電子メールで送信ADS adapted from 2009 CRS poster,The Influence of Coating System Type on Acetaminophen Release from Ethylcellulose Barrier Membrane Coated Multiparticulates
CRS 2009 - Investigation of Aqueous Ethylcellulose Dispersion in ER Metformin Inert Matrices
ドキュメントのダウンロード 電子メールで送信CRS 2010 - Influence of Hydrophilic Pore-Formers on Metoprolol Succinate Release from Mini-tabs Coated with Aqueous Ethylcellulose Dispersion
ドキュメントのダウンロード 電子メールで送信CRS 2010 - Stability of a Sparingly Soluble BCS Class I API Ethylcellulose Coated Multiparticulate
ドキュメントのダウンロード 電子メールで送信Investigating the long term stability, curing effects and release kinetics of a sparingly soluble BCS Class I API, layered on nonpareil beads and coated with Surelease.
CRS 2011 - Barrier Membrane Coating of Hydrophilic Matrices: A Strategy to Reduce Drug Release Variability and Possible Food Effect
ドキュメントのダウンロード 電子メールで送信Application of a barrier membrane (BM) coating with Surelease including a pore-former (Opadry system); with near zero order drug release profiles obtained.
CRS 2011 - Barrier Membrane Coating of Hydrophilic Matrices: Influence of Tablet Shape and Geometry on Drug Release
ドキュメントのダウンロード 電子メールで送信An opportunity for tailoring the drug release profile in addition to rebranding of existing products,and creating distinctive formulations.
CRS 2011 - Influence of Aqueous Ethylcellulose Coating on the Performance of Hydrophilic Polyethylene Oxide Mini-Matrices Containing a Freely Water Soluble Drug
ドキュメントのダウンロード 電子メールで送信CRS 2012 - Barrier Membrane Coating of Hydrophilic Matrices of a Very Soluble Drug, Metoprolol Tartrate at High Dose: A Strategy to Eliminate the Initial Burst Release
ドキュメントのダウンロード 電子メールで送信Application of barrier membrane (BM) coating, using Surelease with a pore-former, Opadry; elimination of the burst effect, followed by near zero order release.
CRS 2013 - Barrier Membrane Coating of Hydrophilic Matrices: A Simplified Strategy to Attain Zero Order Drug Release
ドキュメントのダウンロード 電子メールで送信Alternative formulation strategy for dosage forms where zero order release of drug is desired
CRS 2015 - Taste-masking Performance from Coated Granules & Chewable Tablets
ドキュメントのダウンロード 電子メールで送信Taste-masking of a bitter drug, acetaminophen (APAP) was achieved by application of a Surelease and HPMC-based Opadry combination coating.
CRS 2018 - Application of Barrier Membrane Coating to Reduce the Weight of Metformin HCI Extended Release Tablets
ドキュメントのダウンロード 電子メールで送信ホワイトペーパー/記事
Bitter to Better: Formulation Strategies for Effective Taste Masking
ドキュメントのダウンロード 電子メールで送信April 2018 Article Tablets and Capsules Magazine, Author Charles Vesey
Film Coating for Pediatric Oral Solid Dosage Forms
ドキュメントのダウンロード 電子メールで送信Getting the Right Coating for Pediatric Tablet Formulations
Film Coating for Taste-masking of Pediatric Oral Solid Dosage Forms
ドキュメントのダウンロード 電子メールで送信Case study on the use of Surelease® and Opadry® in the Development of a Paediatric Form of Raltegravir
On Drug Delivery
ドキュメントのダウンロード 電子メールで送信Taste-masking interview from On Drug Delivery July 2015 edition. Taste-masking and the positive impact on medication adherence. Review of pH dependent and independent film coating options.
