CRS 2013 - Consideration of Critical Material Attributes in Hypromellose-Based Hydrophilic Matrices Comprising Drugs of Various Solubility

Case studies using theophylline (water solubility 8.3 mg/ml) or HCTZ (water solubility ~0.7 mg/ml) with METHOCEL K4M and Starch 1500 as the matrix former