Functional Excipients for the Formulation of Solid Oral Dosage Forms
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Applications
Assessment of Low-Dose Content Uniformity of IndomethacinAcademic poster comparing three excipients and their role in achieving content uniformity in a formula containing a very low dose of indomethacin.
Formulation and Processing Options for an Amlodipine Besylate TabletStudy evaluating the effects of formulation and manufacturing process on an amlodipine besylate tablet. A base of microcrystalline cellulose and Starch 1500 produced an excellent product with high mechanical strength, fast dissolution, stable stablity, and good process flexibility that was superior to DCP in many aspects.
Use of Starch 1500® to Improve the Uniformity of a Low Dose Direct Compression Chlorpheniramine FormulationThis study examines the effect of Starch 1500 as an agent for pre-blending a low dose active to ensure good uniformity in a direct compression chlorpheniramine maleate (4mg) formulation.
Formulation of Low Dose Medicines - Theory and PracticeAn article written by Hashim Ahmed, Ph.D. and Navnit Shah, Ph.D. of Hoffmann-LaRoche Inc. evaluating multiple excipients for content uniformity in a low dose application.
Effectiveness of Moisture Barrier Coatings on Various Tablet CoresEvaluation of Opadry® AMB compared with alternative coating formulations and their effect on moisture uptake.
Opadry® AMB - Moisture Vapor TransmissionEvaluation of Opadry AMB compared with alternative coating formulations and their effect on moisture uptake.
Correlation of Free Salicylic Acid Content to the Water Vapor Transmission Properties of Aqueous Film Coating SystemsEffective moisture protection of a solid oral dosage from an aqueous film coating system.
Direct Compression Formula using Starch 1500® with Ranitidine HCL (150mg) Tablets, Film Coated with Opadry® II (85 Series)Data demonstrating the ability of a formulator challenged with a moisture sensitive active to produce a robust dosage with excellent physical and chemical stability utilizing Starch 1500 in the core and Opadry II as the film coat.
Free and Bound Water in Starch 1500® compared to other commonly used excipientsComparison of Water Activity v LOD of commonly used excipients.
The Effect of Starch 1500® on the Stability of Aspirin Tablets Stored Under Accelerated ConditionsPresents data to suggest that Starch 1500 may be inhibiting water activity within the formulation and retarding moisture interaction with the aspirin.
Development of Ultra High-Dose Formulation of Traditional Chinese Medicine (TCM) Extract Tablets by Fluid Bed Granulation ProcessThe use of Starch 1500 as a substitute for PVP and superdisintigrant minimizes the complexity of the formula and offers significant excipient cost reductions.
Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film CoatingThe goal of this study was to determine which combination of excipients would result in an Aspirin tablet core that would be suitable for use in an aqueous enteric film-coating process.
Application of Acryl-EZE® 93F on Rabeprazole Sodium Tablets (20 mg) This poster reprint demonstrates the successful use of Acryl-EZE 93F19255, when applied onto rabeprazole sodium tablets.
Aqueous Enteric Coating Application on Non-Banded Hard Gelatin Capsules This poster reprint investigates the delayed release performance of Acryl-EZE® 93F19255, when applied onto omeprazole filled, hard gelatin capsules.
Controlled Permeability Films for Programmable Drug ReleaseThis poster reprint investigates the influence of sodium alginate or hypromellose (HPMC) as pore formers in a delayed release film coating to achieve modified enteric drug release.
Enteric Coating of Tablets with Debossed LogosThis poster reprint demonstrates how to successfully enteric coat tablets which contain a debossed logo.
New Coating Process for the Application of Enteric Coatings to Small Tablet SamplesThis poster reprint investigates the rapid application of an aqueous enteric coating system onto very small batch sizes of tablets using a novel coating process technology, the SUPERCELL™ process from Niro.
Preparation of Robust, Enteric-Coated Dosage Forms Utilizing Acryl-EZE®This poster reprint provides solutions for the application of aluminum lake pigmented Acryl-EZE formulations onto various actives, to provide stable, reproducible drug release.
Preparation of Stable, Gastro-Resistant Diclofenac Sodium Tablets, Utilizing Optimized Film-Coating Combinations with Acryl-EZE®This poster reprint demonstrates how to reduce your overall coating process time and achieve drug product stability, by incorporating pigments directly into the Acryl-EZE enteric film layer.
Production-Scale Process and Performance Comparison of Two Fully-Formulated Aqueous Enteric Coating SystemsThis poster reprint summarizes the production scale evaluation of Acryl-EZE® and Sureteric® for coating process, enteric protection, and finished product stability.
The Effect of Superdisintegrant on Acid Resistance of Enteric Coated TabletsThis poster reprint investigates the influence of superdisintegrant type and level on the performance of two enteric coated tablet formulations.
The Influence of Gastric Media (In-Vitro) on the Performance of Delayed Release Proton Pump Inhibitor Dosage FormsThis poster reprint investigates the enteric performance of aqueous enteric-coated tablet formulations containing proton pump inhibitors (PPI’s) in bio-relevant media, which better simulates the gastric environment of a patient on a multiple dose regimen of PPI’s.
Effect of Hypromellose as a Pore-Former in Aqueous Ethylcellulose Dispersion: Characterization of Dispersion PropertiesThis poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
Hypromellose as a Pore Former in Aqueous Ethylcellulose Dispersion: Stability and Film PropertiesThis poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose CoatingThis poster reprint summarizes the effect of pore former on the drug release of various actives from drug layered beads coated with Surelease®, aqueous ethylcellulose dispersion.
Predictability of Drug Release from Multiparticulate Systems Coated with an Aqueous Ethylcellulose DispersionThis poster reprint examines drug release from drug layered beads varying in substrate size, and Surelease® coating level.
The Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Non-Pareil BeadsThis poster reprint investigates the influence of pore-formers on the release of a poorly water-soluble drug, dipyridamole, from non-pareil beads coated with an aqueous ethylcellulose dispersion (Surelease® NG E-7-19050).
Opadry® tm - Taste Mask ComparisonProduct technology summary including stability profile, film properties, color effects and regulatory guidelines.
Taste Masking Performance and Stability of Opadry® tmTaste and dissolution profile studies of Bitrex and Caffeine tablet cores coated with Opadry tm.
