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Applications
Assessment of Low-Dose Content Uniformity of IndomethacinThis ADS was adapted from an academic poster comparing three excipients and their role in achieving content uniformity in a formula containing a very low dose of indomethacin.
Formulation and Processing Options for an Amlodipine Besylate TabletStudy evaluating the effects of formulation and manufacturing process on an amlodipine besylate tablet. A base of microcrystalline cellulose and Starch 1500 produced an excellent product with high mechanical strength, fast dissolution, stable stablity, and good process flexibility that was superior to DCP in many aspects.
Use of Starch 1500® to Improve the Uniformity of a Low Dose Direct Compression Chlorpheniramine FormulationThis study examines the effect of Starch 1500 as an agent for pre-blending a low dose active to ensure good uniformity in a direct compression chlorpheniramine maleate (4mg) formulation.
Formulation of Low Dose Medicines - Theory and PracticeAn article written by Hashim Ahmed, Ph.D. and Navnit Shah, Ph.D. of Hoffmann-LaRoche Inc. evaluating multiple excipients for content uniformity in a low dose application.
Investigation of Ethylcellulose in the Preparation of Theophylline Extended Release Inert Matrix TabletsThis research illustrates the influence of EC particle size and molecular weight on drug release from inert matrices containing a sparingly water soluble drug. The influence of varying the polymer concentration, filler choice and compression force on drug release was also evaluated.
Effect of Processing Conditions on Hypromellose Matrix Formulations of Acetaminophen Prepared by a High Shear Wet Granulation ProcessThis ADS was adapted from the CRS 2010 poster providing processing guidelines for developing a hypromellose matrix formulation using a wet granulation process; with the extra-granular addition of HPMC and Starch 1500 resulting in increased tablet hardness.
Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl Extended Release MatricesADS adapted from 2009 CRS poster, Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl Extended Release Matrices
Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose Matrices at Constant Surface Area to Volume Ratio Using Two Model DrugsADS adapted from 2009 CRS poster, Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose Matrices at Constant Surface Area to Volume Ratio Using Two Model Drugs
The Influence of Hydro-Alcoholic Media on Hypromellose Matrix SystemsThis ADS was adapted from the 2006 AAPS poster investigating the effect of hydro-alcoholic dissolution media on the swelling and drug release properties of METHOCEL™ matrices.
The Utility of Ultra-High Viscosity Hypromellose in Extended Release Matrix FormulationsThis ADS was adapted from the CRS 2010 poster showing that the use of ultra-high viscosity BENECEL K200M in an extended release matrix system did not show any advantage in drug release retardation compared to METHOCEL K100M.
The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release MatricesThis ADS was adapted from the 2008 AAPS poster. The objective of this study was to investigate the influence of different dissolution methods on the release of a high solubility drug from an ER matrix formulation containing either HPMC or PEO as the rate-controlling polymer.
Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices ADS adapted from 2009 CRS poster, Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices
Investigation of Mini-Tab Capsule Filling Using a Zanasi Lab 16 MachineThis study investigated the possibility of filling 2 mm diameter coated placebo mini-tabs into capsules size 0, using a Zanasi Lab 16 (IMA) capsule filling machine.
The Influence of Hydrophilic Pore-Formers on Metoprolol Succinate Release from Mini-tabs Coated with Aqueous Ethylcellulose DispersionThis ADS was adapted from the CRS 2010 poster to investigate the influence of incorporating different levels of pore-former into aqueous EC system (Surelease) on the release of a freely water-soluble drug metoprolol succinate, from coated mini-tabs.
Correlation of Free Salicylic Acid Content to the Water Vapor Transmission Properties of Aqueous Film Coating SystemsThis study investigates the water vapor transmission (WVTR) properties of common aqueous film coating polymers and fully formulated coating systems.
Effectiveness of Moisture Barrier Coatings on Various Tablet CoresEvaluation of Opadry® amb compared with alternative coating formulations and their effect on moisture uptake.
Opadry® amb - Moisture Vapor TransmissionEvaluation of Opadry amb compared with alternative coating formulations and their effect on moisture uptake.
Opadry® fx™ Enhanced Moisture Protection and Film PropertiesCharacterization of moisture vapor transmission rate and other film properties of Opadry fx.
Opadry® 200 - Product Information BrochureFully formulated, one-step, PVA (polyvinyl alcohol)-based film coatings that offer a high-level of protection combined with fast coating process times and improved final product stability.
AAPS 2010 - Novel Immediate Release Coating Offering Excellent Coating Productivity, Moisture Barrier and Drug Release Composition Based on PVA and an Acrylic PolymerThe aim of this study was to characterize a novel fully formulated film coating comprised of polyvinyl alcohol and an acrylic polymer. The novel film coating studied offers high productivity with enhanced moisture barrier functionality and no impact on drug release compared to uncoated tablets..
Direct Compression Formula using Starch 1500® with Ranitidine HCL (150mg) Tablets, Film Coated with Opadry® II (85 Series)Data demonstrating the ability of a formulator challenged with a moisture sensitive active to produce a robust dosage with excellent physical and chemical stability utilizing Starch 1500 in the core and Opadry II as the film coat.
Free and Bound Water in Starch 1500® compared to other commonly used excipientsComparison of Water Activity v LOD of commonly used excipients.
The Effect of Starch 1500® on the Stability of Aspirin Tablets Stored Under Accelerated ConditionsPresents data to suggest that Starch 1500 may be inhibiting water activity within the formulation and retarding moisture interaction with the aspirin.
Development of Ultra High-Dose Formulation of Traditional Chinese Medicine (TCM) Extract Tablets by Fluid Bed Granulation ProcessThe use of Starch 1500 as a substitute for PVP and superdisintigrant minimizes the complexity of the formula and offers significant excipient cost reductions.
Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film CoatingThe goal of this study was to determine which combination of excipients would result in an Aspirin tablet core that would be suitable for use in an aqueous enteric film-coating process.
Application of Powder Layering Technology and Aqueous Enteric CoatingThis ADS was adapted from the AAPS 2006 poster demonstrating the successful use of Acryl-EZE® 93F19255, when applied onto dry powder layered lansoprazole multiparticulates.
Evaluation of the Enteric Performance of Lansoprazole Mini-Tabs Coated in a Perforated PanThe focus of this study was to investigate the potential of successful manufacture and enteric coating of lansoprazole mini-tabs using methacrylic acid co-polymers in a perforated pan. Along with other findings, this study will show that the mechanical strength of the mini-tabs significantly improved upon application of a seal-coat.
Investigation of Venlafaxine HCl Release from Extruded and Spheronized Beads Coated with Ethylcellulose using Organic or Aqueous Coating SystemsThe objective of this study was to investigate the overall performance of an extruded and spheronized formulation containing venlafaxine HCl, a highly water soluble drug (572 mg/mL)(3), coated with ethylcellulose from organic or aqueous systems.
The Influence of Pore-Former on Drug Release from Ethylcellulose Coated MultiparticulatesThis poster was presented at the 2010 CRS meeting in Portland, OR. The objective of this work was to investigate the influence of HPMC as a pore-former on the release of chlorpheniramine maleate from multiparticulate beads coated with ethylcellulose from an organic solution.
The Influence of Solvent Type on Extended Release Coating with Ethylcellulose Barrier MembranesThe objective of this work was to investigate the influence of four acceptable solvent combinations on EC solution viscosity and consequent drug release from coated beads.
The Influence of Plasticizer Type and Level on Drug Release from Ethylcellulose Barrier Membrane MultiparticulatesADS adapted from 2009 CRS poster, The Influence of Plasticizer Type and Level on Drug Release from Ethylcellulose Barrier Membrane Multiparticulates
Stability of a Sparingly Soluble BCS Class I API Ethylcellulose Coated MultiparticulateThis ADS was adapted from the CRS 2010 poster investigating the long term stability, curing effects and release kinetics of a sparingly soluble BCS Class I API, layered on nonpareil beads and coated with aqueous Ethylcellulose dispersion.
Application of an Aqueous Ethylcellulose Dispersion in Multiple-Unit Pellet Systems.The objective of this poster reprint was to investigate drug release from compressed multiple-unit pellet systems, coated with an aqueous ethylcellulose dispersion (Surelease® E-7-19040).
Comparative Study of Theoretical Versus Actual Weight Gain for a Surelease® Barrier Membrane on Coated PelletsThis poster reprint outlines an analytical method to determine the quantity of ethylcellulose applied during coating, on multiparticulates.
Effect of Hypromellose as a Pore-Former in Aqueous Ethylcellulose Dispersion: Characterization of Dispersion PropertiesThis poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
Identification and Influence of Critical Coating Process Parameters on Drug Release from a Fully Formulated Aqueous Ethylcellulose DispersionThe objective of this poster reprint was to identify and study the influence of critical film coating process parameters for Surelease® aqueous ethylcellulose dispersion, on drug release behavior and the output or response variables of that process.
Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose CoatingThis poster reprint summarizes the effect of pore former on the drug release of various actives from drug layered beads coated with Surelease®, aqueous ethylcellulose dispersion.
Predictability of Drug Release from Multiparticulate Systems Coated with an Aqueous Ethylcellulose DispersionThis poster reprint examines drug release from drug layered beads varying in substrate size, and Surelease® coating level.
The Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Non-Pareil BeadsThis poster reprint investigates the influence of pore-formers on the release of a poorly water-soluble drug, dipyridamole, from non-pareil beads coated with an aqueous ethylcellulose dispersion (Surelease® NG E-7-19050).
The Influence of Post Coating Thermal Treatment on Film Properties and Drug Release from Ethylcellulose Barrier Membrane Coating SystemsThe results of this study demonstrate that post coating treatment can affect both physico-mechanical properties of EC films and drug release from EC-coated multi-particulates.
Application of Acryl-EZE® 93F on Rabeprazole Sodium Tablets (20 mg) This ADS was adapted from the 2006 AAPS poster demonstrating the successful use of Acryl-EZE 93F19255, when applied onto rabeprazole sodium tablets.
Aqueous Enteric Coating Application on Non-Banded Hard Gelatin Capsules This ADS was adapted from the 2006 AAPS poster that investigates the delayed release performance of Acryl-EZE® 93F19255, when applied onto omeprazole filled, hard gelatin capsules.
Controlled Permeability Films for Programmable Drug ReleaseThis ADS was adapated from the 2006 CRS poster investigating the influence of sodium alginate or hypromellose (HPMC) as pore formers in a delayed release film coating to achieve modified enteric drug release.
Enteric Coating of Tablets with Debossed LogosThis ADS was adapated from the 2004 CRS poster demonstrating how to successfully enteric coat tablets which contain a debossed logo.
New Coating Process for the Application of Enteric Coatings to Small Tablet SamplesThis ADS was adapted from the 2005 AAPS poster investigating the rapid application of an aqueous enteric coating system onto very small batch sizes of tablets using a novel coating process technology, the SUPERCELL™ process from Niro.
Preparation of Robust, Enteric-Coated Dosage Forms Utilizing Acryl-EZE®This ADS was adapted from the 2002 AAPS poster providing solutions for the application of aluminum lake pigmented Acryl-EZE formulations onto various actives, to provide stable, reproducible drug release.
Preparation of Stable, Gastro-Resistant Diclofenac Sodium Tablets, Utilizing Optimized Film-Coating Combinations with Acryl-EZE®This ADS was adapted from the 2003 CRS poster demonstrating how to reduce your overall coating process time and achieve drug product stability, by incorporating pigments directly into the Acryl-EZE enteric film layer.
Production-Scale Process and Performance Comparison of Two Fully-Formulated Aqueous Enteric Coating SystemsThis ADS was adapted from the 2001 AAPS poster summarizing the production scale evaluation of Acryl-EZE® and Sureteric® for coating process, enteric protection, and finished product stability.
The Effect of Superdisintegrant on Acid Resistance of Enteric Coated TabletsThis ADS was adapted from the 2005 AAPS poster investigating the influence of superdisintegrant type and level on the performance of two enteric coated tablet formulations.
The Influence of Gastric Media (In-Vitro) on the Performance of Delayed Release Proton Pump Inhibitor Dosage FormsThis ADS was adapated from the 2005 AAPS poster investigating the enteric performance of aqueous enteric-coated tablet formulations containing proton pump inhibitors (PPI’s) in bio-relevant media, which better simulates the gastric environment of a patient on a multiple dose regimen of PPI’s.
Modulation of Drug Release from Hydrophilic MatricesThis article examines the concept of synergies between hypromellose and other polymers to modulate the drug release rate from matrix dosage forms.
Development of Diclofenac Sodium Delayed Release Tablets USP Opadry® Enteric (94 Series)This study highlights the use of an Opadry® Enteric film coating for producing delayed-release diclofenac tablet formulations which meet current USP specifications.
Drug Release From Acrylic-Based Opadry® Enteric (94 Series) Coated TabletsOpadry® Enteric (94 Series), enteric coating system, is a fully formulated, delayed release coating system for solid oral dosage forms that is based on MAC, specifically the poly [methacrylic acid, methyl methacrylate (1:1), type A].
Opadry® Enteric 91, 94, 95 seriesOpadry Enteric is a family of fully formulated, delayed release coating systems for solid oral dosage forms, which are applied by organic or hydro-alcoholic processing techniques.
Hypromellose as a Pore Former in Aqueous Ethylcellulose Dispersion: Stability and Film PropertiesThis poster reprint investigates the effect of HPMC as a pore-former on: stability of aqueous EC dispersion (Surelease®); quality of the free films prepared from these mixtures, and interactions between the HPMC and EC dispersion.
Opadry® tm - Taste Mask ComparisonProduct technology summary including stability profile, film properties, color effects and regulatory guidelines.
Taste Masking Performance and Stability of Opadry® tmTaste and dissolution profile studies of Bitrex and Caffeine tablet cores coated with Opadry tm.
