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Application of Opadry® II, complete film coating system, on metformin HCl extended release matrices containing POLYOX™ water soluble resinApplication Data on Polyox
Dissolution Testing for POLYOX™ Extended Release MatricesApplication Data on Polyox
Evaluation of Various Materials for Cleaning of Processing Area and Equipment After Using POLYOX™ PolymersApplication Data for Polyox
Formulation of POLYOX™ ER Matrices for a Highly Soluble ActiveApplication Data
Physico-mechanical Characterization of POLYOX™ for Tablet ManufactureApplication Data on Polyox
The Influence of In Vitro Dissolution Method on the Release of a Highly Water Soluble Drug from Polyethylene Oxide and Hypromellose Hydrophilic Extended Release MatricesThis ADS was adapted from the 2008 AAPS poster. The objective of this study was to investigate the influence of different dissolution methods on the release of a high solubility drug from an ER matrix formulation containing either HPMC or PEO as the rate-controlling polymer.
POLYOX™ Product Information BrochureIntroduction to the POLYOX™ line of water soluble resins.
AAPS 2010 - The Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide Extended Release Matrix TabletsThe aim of this study was to investigate the influence of hydro-alcoholic media on the release rate of two model APIs with various aqueous solubility (gliclazide and metformin HCl) from PEO ER matrices.
AAPS 2010 - The Influence of Polymer Concentration on Release of Poorly Soluble Drugs from Polyethylene Oxide Extended Release MatricesThe aim of this study was to investigate the influence of PEO concentration on the release of poorly water soluble APIs from ER matrices.
AAPS 2011 - Effect of Formulation and Granulation Processing Parameters on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugPush-pull osmotic pumps (PPOP) of a practically insoluble model drug (Drug Y) were developed. The purpose is to evaluate the effect of tablet formulation and granulation processing on performance of PPOP tablets of this model drug.
AAPS 2011 - Effect of Semipermeable Coating Composition and Opadry® Top-Coating Systems on Performance of Push-Pull Osmotic Pump Tablets of a Practically Water Insoluble Model DrugThe objective of this study is twofold: (i) to investigate the effect of the semipermeable coating composition comprising cellulose acetate along with different grades of polyethylene glycol (PEG); and (ii) to evaluate the effect of various Opadry film coating systems, on performance of the developed PPOPs.
AAPS 2011 - The Effect of Film Coating on the Stability of Extended Release Metformin Hydrochloride POLYOX™ MatricesThe aim of this study was to investigate the effect of an Opadry® II film coating system on the stability of metformin HCl extended released (ER) polyethylene oxide (POLYOX™) matrix tablets.
CRS 2011 - Development of Push Pull Osmotic Pump Tablets for a Slightly Soluble Model DrugResults showed that irrespective of the multiple steps involved in manufacture of such dosage forms, developed tablets demonstrated equivalent performance to commercial tablets with respect to physical properties, drug release and push-pull pattern. The developed system could provide a platform to yield satisfactory results for similar drug candidates.
CRS 2011 - Effect of Different Processing Conditions on the Performance of Push Pull Osmotic Pump Tablets of a Slightly Soluble Model DrugPush-Pull Osmotic Pump (PPOP) tablets of a slightly water soluble model drug were developed. The effects of tablet mechanical strength, drying method of granules and methods of tablet manufacture (manual vs. rotary tablet press) on performance of PPOP tablets. The findings of this study showed a robust osmotic system which could yield satisfactory results for similar drug candidates.
CRS 2011 - The Influence of Film Coating and Storage on Propranolol Hydrochloride Release from Polyethylene Oxide Extended Release MatricesPolyethylene oxide (PEO) is prone to autoxidation, leading to chain cleavage and reduction of polymer viscosity on storage.Robust POLYOX™ ER matrices containing model drug propranolol HCl were produced, the mechanical strength of which was significantly improved by the application of 3% WG of an Opadry II® film coating.
CRS 2011 - The Influence of Sodium Carboxymethyl Cellulose on Drug Release from Polyethylene Oxide Extended Release MatricesPolyethylene oxide (POLYOX™) and sodium carboxymethyl cellulose can be used to modulate the release of various drugs. Potential synergistic interaction can be used to design new oral ER pharmaceutical dosage forms with more prolonged release using lower polymer amounts, which could be particularly beneficial for freely or very water-soluble drugs, where accommodation of high doses is required and once daily administration is preferred.
Development of Push Pull Osmotic Pump Tablets for a Slightly Soluble Model DrugResults showed that irrespective of the multiple steps involved in manufacture of such dosage forms, developed tablets demonstrated equivalent performance to commercial tablets with respect to physical properties, drug release and push-pull pattern. The developed system could provide a platform to yield satisfactory results for similar drug candidates.
Effect of Different Processing Conditions on the Performance of Push Pull Osmotic Pump Tablets of a Slightly Soluble Model DrugPush-Pull Osmotic Pump (PPOP) tablets of a slightly water soluble model drug were developed. The effects of tablet mechanical strength, drying method of granules and methods of tablet manufacture (manual vs. rotary tablet press) on performance of PPOP tablets. The findings of this study showed a robust osmotic system which could yield satisfactory results for similar drug candidates.
Effect of Filler Type on the Stability of Polyethylene Oxide in a Hydrophilic Matrix TabletThe effect of various fillers on the oxidative stability of polyethylene oxide (PEO) in a matrix tablet was studied. Tablet hardness, dissolution profiles, and polymer viscosity were studied over 3 months at accelerated aging conditions. Results indicate PEO stability can be affected by the type of filler used in the formulation.
The Influence of Hydro-Alcoholic Media on Drug Release from Polyethylene Oxide Extended-Release Matrix TabletsPublished article reprint that summarizes extended-release of PEO tablets of the practically water insoluble drug gliclazide (30 mg) and freely soluble metformin HCl (500 mg) when exposed to 5% and 40% w/v ethanol solutions for up to 12 h.
