Functional Excipients for the Formulation of Solid Oral Dosage Forms
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Dow METHOCEL™ Literature
Bi-Phasic Drug Release from Drug Layered, Extended Release Hypromellose MatricesThis ADS was adapted from the 2007 AAPS poster summarizing a process utilized to achieve an immediate and extended release profile from an HPMC matrix system.
Direct Compression Metformin HCl 500mg Extended Release Formula Based on HypromelloseThis ADS was adapted from the 2005 CRS poster investigating the formulation of an extended release, direct compression Metformin HCl (500 mg) matrix tablet using METHOCEL™.
Effect of Processing Conditions on Hypromellose Matrix Formulations of Acetaminophen Prepared by a High Shear Wet Granulation ProcessThis ADS was adapted from the CRS 2010 poster providing processing guidelines for developing a hypromellose matrix formulation using a wet granulation process; with the extra-granular addition of HPMC and Starch 1500 resulting in increased tablet hardness.
Evaluation of Verapamil HCl (240 mg) Extended Release Matrix Formulations This ADS was adapted from the 2006 AAPS poster investigating the use of dissolution testing apparatus III and biorelevant dissolution media as a means to better understand the in-vivo release of drug from METHOCEL™ matrices.
Evaluation of the Effect of Hydroalcoholic Media on Textural and Rheological Characteristics of Hypromellose MatricesThis ADS was adapated from the 2007 CRS poster investigating the effect of hydro-alcoholic dissolution media on the textural properties of METHOCEL™ matrices, and rheological properties of METHOCEL solutions.
Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl Extended Release MatricesADS adapted from 2009 CRS poster, Investigation of Moisture-Activated Granulation of Hydrophilic Polymer Blends in Verapamil HCl Extended Release Matrices
Investigation of a Venlafaxine HCl (37.5mg) Extended Release Formulation using Hypromellose (HPMC) MatricesThis ADS was adapted from the 2006 CRS poster which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices. Granulation of the drug, and coating on top of the matrix, with Surelease, were investigated.
Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose Matrices at Constant Surface Area to Volume Ratio Using Two Model DrugsADS adapted from 2009 CRS poster, Investigation of the Effect of Tablet Geometry and Film Coating on Drug Release from Hypromellose Matrices at Constant Surface Area to Volume Ratio Using Two Model Drugs
Investigation of the Effects of Hydro-Alcoholic Media on Rheological and Textural Properties of Various Grades of Hypromellose (HPMC)This ADS was adapted from the 2007 AAPS poster expanding on previously reported work which investigated the effect of hydro-alcoholic dissolution media on the textural properties of METHOCEL™ matrices, and rheological properties of METHOCEL solutions.
Maintaining Similar Drug Release from Hypromellose Matrices with Identical Dimensions but Different Dose StrengthsThis ADS provides a method to maintain similar drug release, tablet shape and weight, from a METHOCEL™ matrix, while adjusting the drug dose.
Mathematical Model for Simulation and Control of Drug Release from Hydrophilic MatricesThis ADS was adapted from the 2007 CRS poster which utilizes mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL™ matrices.
Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst EffectThis ADS was adapted from the 2006 AAPS poster which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices.
Particle Swelling and Coalescence to Gel Layer FormationThis ADS was adapted from the 2005 AAPS poster investigating swelling and coalescence behavior of hydroxypropylmethyl cellulose (HPMC) and partially pregelatinised starch particles, in order to monitor the contribution to gel layer formation in mixed HPMC and Starch 1500® matrices.
The Effect of Film Coating and Storage Conditions on the Performance of Metformin HCl 500 mg Extended Release Hypromellose MatricesThis ADS was adapted from the 2006 CRS poster investigating the influence of three film coating systems on the performance of Metformin HCl (500mg) extended release (ER) Hypromellose matrices stored under different conditions up to 12 months.
The Effect of In Vitro Dissolution Parameters on the Release Rate of a Low Dose, Low Solubility Drug from Extended Release Hypromellose Matrix Formulations This ADS was adapted from the 2006 CRS poster examining the impact of dissolution testing parameters on a low dose, low solubility, METHOCEL™ matrix formulation, compared to a marketed reference product.
The Influence of Anionic Polymers on Hydrochlorothiazide Extended Release Hypromellose MatricesThis ADS was adapted from the 2007 AAPS poster summarizing the effect of blending anionic polymers (carbomer and polyvinyl acetate phthalate [PVAP, Phthalavin®]) with HPMC, on extending the release of a very slightly soluble drug (~1.0 mg/ml). The effects of varying the polymer blend ratio and excipient choice were studied in terms of drug release profile and textural properties of the hydrated matrix tablets.
The Influence of Film Coatings on Performance of Hypromellose MatricesThis ADS was adapated from the 2003 CRS poster which examines the influence of various immediate release film coatings on the drug release from METHOCEL™ matrices.
The Influence of Formulation Variables on Drug Release Kinetics from Hypromellose Extended Release MatricesThis ADS was adapted from the 2006 CRS poster which utilizes mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL™ matrices.
The Influence of Hydro-Alcoholic Media on Hypromellose Matrix SystemsThis ADS was adapted from the 2006 AAPS poster investigating the effect of hydro-alcoholic dissolution media on the swelling and drug release properties of METHOCEL™ matrices.
The Influence of Hydrodynamic Conditions on Verapamil Hydrochloride Release from Hydrophilic Matrices Using Ionic and Non-Ionic PolyersThis ADS was adapted from the 2008 AAPS poster. The purpose of this study was to investigate the effects of hydrodynamic conditions on drug release rates from a matrix tablet with a soluble active ingredient, using different combinations of HPMC. The study will show that the combination of HPMC with ionic polymers in ER matrices provides robust formulations which are insensitive to hydrodynamic conditions.
The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240mg) Extended Release FormulationThis ADS was adapted from the 2005 CRS poster examining the impact of the type of dissolution testing method on drug release from extended release verapamil hydrochloride METHOCEL™ matrices.
Use of Roller Compaction in the Preparation of Verapamil Hydrochloride Extended Release Matrix Tablets Containing Hydrophilic PolymersThis ADS was adapted from the 2008 CRS poster evaluating the effects of roller compaction on the flow and compressibility of blends of HPMC, polyvinyl acetate phthalate(PVAP) and carbomer [cross-linked poly (acrylicacid)]. Drug release of an ER verapamil HCl matrix formulation containing this blend was also evaluated.
An Introduction to METHOCEL™ Cellulose EthersA description of the METHOCEL line of premium cellulose ethers.
Blending for Intermediate ViscosityThis product data sheet demontrates how to blend existing viscosity grades of METHOCEL™ to obtain an intermediate viscosity grade.
General Properties of METHOCEL™ Premium Cellulose EthersThis product data sheet describes chemical and physical properties of METHOCEL premium cellulose ethers.
How to Prepare Aqueous Solutions of METHOCEL™This product data sheet describes how to prepare aqueous solutions of METHOCEL.
How to Prepare Solutions of METHOCEL™ in Nonaqueous SolventsThis product data sheet describes how to prepare solutions of METHOCEL from non-aqueous solvents.
HyperStart® Formulation Service: Predicting Performance and Accelerating DevelopmentIntroduction to the HyperStart formulation service for hydrophilic matrix systems.
Properties of Solutions of METHOCEL™This product data sheet describes the properties of METHOCEL solutions.
Using METHOCEL™ Cellulose Ethers for Controlled Release of Drugs in Hydrophilic Matrix SystemsThis product data summarizes the application of METHOCEL premium cellulose ethers in extended release, hydrophilic matrix formulations.
Controlled Release Alliance BrochurePromotional booklet which outlines the Colorcon/Dow Wolff Cellulosics Controlled Release Alliance.
METHOCEL™ Product Information BrochureIntroduction to the METHOCEL™ platform of water soluble cellulose ethers.
AAPS 2010 - Application of Quality by Design (QbD) Principles to the Formulation of Extended Release Propranolol Hydrochloride Hydrophilic Matrix TabletsThe objective of this study was to investigate the effects of variation in hypromellose physico-chemical properties on powder flow, tablet physical properties and in vitro drug release profiles, from an extended release hydrophilic matrix tablet using QbD principles.
AAPS 2010 - Effect of Filler Type on Low Dose Acetaminophen Hydrophilic Matrix Formulations Prepared by a High Shear Wet Granulation ProcessThe objective of this study was to investigate the effect of four commonly used fillers in formulation and processing of HPMC matrices utilizing a high shear wet granulation process.
AAPS 2011 - The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide and Hypromellose Extended Release MatricesTo investigate the influence of ionic polymer sodium carboxymethylcellulose (NaCMC) on the release of a freely water-soluble (572 mg/mL11) model drug, venlafaxine hydrochloride, from ER formulations containing non-ionic polymers, PEO or HPMC, as matrix formers. The performance of PEO and HPMC was compared. Additionally, the effect of polymer concentration (30 or 50% w/w) on drug release was studied.
CRS 2011 - Application of Quality by Design (QbD) Principles to the Formulation of Extended Release Theophylline Hydrophilic Matrix TabletsThe objective of this study was to investigate the effects of hypromellose physicochemical properties on powder flow, tablet physical properties and in vitro drug release profiles from an extended release hydrophilic matrix tablet using QbD principles.
Comparison of Swelling, Erosion, and Gel Strength of Polyethylene Oxide and HypromelloseThe objective of this study was to compare swelling, erosion, and gel strength of commonly used hydrophilic polymers for controlled release.
Drug Formulation Studies Using a New Grade of Hypromellose Excipient Designed for Direct-Compression, Controlled-Release ApplicationsA new grade of hypromellose targeted at direct compression tableting was developed. The hypromellose excipient exhibits improved powder flow while retaining the controlled-release performance of hypromellose. The effect of active pharmaceutical ingredient particle size and solubility on tablet properties and controlled-release performance of formulations using the new excipient grade is examined.
Investigation of a Directly Compressible Hypromellose Matrix Formulation for a Low Dose, Practically Insoluble DrugThis poster reprint investigates the formulation of an extended release, direct compression Indapamide (1.5 mg) matrix tablet using METHOCEL™.
Powder Flowability of a New Direct Compression Grade Hypromellose Using Limiting Flow Rate AnalysisThis study applies the concept of limiting flow rates to the new direct compression grade hypromellose and emphasizes its importance as a key measure of flowability for fine materials.
The Utility of Ultra-High Viscosity Hypromellose in Extended Release Matrix FormulationsThis ADS was adapted from the CRS 2010 poster showing that the use of ultra-high viscosity BENECEL K200M in an extended release matrix system did not show any advantage in drug release retardation compared to METHOCEL K100M.
Application of a Modeling System in the Formulation of Extended Release Hydrophilic MatricesThis article reprint describes a predictive formulation service that provides pharmaceutical scientists with a starting formula for hydrophilic matrix tablets.
Applications of Complementary Polymers in HPMC Hydrophilic Extended Release MatricesThis article examines the application of co-formulation of polymers in developing ER hydrophilic matrix systems.
Investigation of the Influence of Tablet Shape, Geometry & Film Coating on Drug Release From Hypromellose Extended-Release MatricesDrug Delivery Technology article published March 2010.
Modulation of Drug Release from Hydrophilic MatricesThis article examines the concept of synergies between hypromellose and other polymers to modulate the drug release rate from matrix dosage forms.
The Influence of Excipients on Drug Release from Hydroxypropyl Methylcellulose MatricesPublished article reprint that summarizes the influence of various excipient fillers on the drug release from METHOCEL™ matrices.
