Functional Excipients for the Formulation of Solid Oral Dosage Forms
Fully Formulated Conventional and Modified Release Film Coating Systems
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Technical Information for Solid Oral Dosage Manufacturing Processes
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Extensive Collection of Articles, Product Literature, Application Data and Regulatory Documents
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Dow METHOCEL™ Literature
Dow METHOCEL™ Technical Presentations
Dow METHOCEL™ Articles
Maintaining Similar Drug Release from Hypromellose Matrices with Identical Dimensions but Different Dose StrengthsThis poster reprint provides a method to maintain similar drug release, tablet shape and weight, from a METHOCEL™ matrix, while adjusting the drug dose.
An Introduction to METHOCEL™ Cellulose EthersA description of the METHOCEL line of premium cellulose ethers.
Blending for Intermediate ViscosityThis product data sheet demontrates how to blend existing viscosity grades of METHOCEL™ to obtain an intermediate viscosity grade.
General Properties of METHOCEL™ Premium Cellulose EthersThis product data sheet describes chemical and physical properties of METHOCEL premium cellulose ethers.
How to Prepare Aqueous Solutions of METHOCEL™This product data sheet describes how to prepare aqueous solutions of METHOCEL.
How to Prepare Solutions of METHOCEL™ in Nonaqueous SolventsThis product data sheet describes how to prepare solutions of METHOCEL from non-aqueous solvents.
HyperStart® Formulation Service: Predicting Performance and Accelerating DevelopmentIntroduction to the HyperStart formulation service for hydrophilic matrix systems.
Properties of Solutions of METHOCEL™This product data sheet describes the properties of METHOCEL solutions.
Using METHOCEL™ Cellulose Ethers for Controlled Release of Drugs in Hydrophilic Matrix SystemsThis product data summarizes the application of METHOCEL premium cellulose ethers in extended release, hydrophilic matrix formulations.
Controlled Release Alliance BrochurePromotional booklet which outlines the Colorcon/Dow Wolff Cellulosics Controlled Release Alliance.
METHOCEL™ Sales BrochureIntroduction to the METHOCEL platform of water soluble cellulose ethers.
Bi-Phasic Drug Release from Drug Layered, Extended Release Hypromellose MatricesThis poster reprint summarizes a process utilized to achieve an immediate and extended release profile from an HPMC matrix system.
Direct Compression Metformin HCl 500mg Extended Release Formula Based on HypromelloseThis poster reprint investigates the formulation of an extended release, direct compression Metformin HCl (500 mg) matrix tablet using METHOCEL™.
Drug Formulation Studies Using a New Grade of Hypromellose Excipient Designed for Direct-Compression, Controlled-Release ApplicationsA new grade of hypromellose targeted at direct compression tableting was developed. The hypromellose excipient exhibits improved powder flow while retaining the controlled-release performance of hypromellose. The effect of active pharmaceutical ingredient particle size and solubility on tablet properties and controlled-release performance of formulations using the new excipient grade is examined.
Evaluation of Verapamil HCl (240 mg) Extended Release Matrix Formulations This article reprint investigates the use of dissolution testing apparatus III and biorelevant dissolution media as a means to better understand the in-vivo release of drug from METHOCEL™ matrices.
Evaluation of the Effect of Hydroalcoholic Media on Textural and Rheological Characteristics of Hypromellose MatricesThis poster reprint investigates the effect of hydro-alcoholic dissolution media on the textural properties of METHOCEL™ matrices, and rheological properties of METHOCEL solutions.
Investigation of a Directly Compressible Hypromellose Matrix Formulation for a Low Dose, Practically Insoluble DrugThis poster reprint investigates the formulation of an extended release, direct compression Indapamide (1.5 mg) matrix tablet using METHOCEL™.
Investigation of a Venlafaxine HCl (37.5mg) Extended Release Formulation using Hypromellose (HPMC) MatricesPoster reprint which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices. Granulation of the drug, and coating on top of the matrix, with Surelease, were investigated.
Investigation of the Effects of Hydro-Alcoholic Media on Rheological and Textural Properties of Various Grades of Hypromellose (HPMC)This poster reprint expands on previously reported work which investigated the effect of hydro-alcoholic dissolution media on the textural properties of METHOCEL™ matrices, and rheological properties of METHOCEL solutions.
Mathematical Model for Simulation and Control of Drug Release from Hydrophilic MatricesThis poster reprint utilizes mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL™ matrices.
Modulation of Drug Release from Hypromellose (HPMC) Matrices: Suppression of the Initial Burst EffectPoster reprint which provides a method to minimize a burst of drug release typically observed in the early phases of release of highly soluble actives from METHOCEL™ matrices.
Particle Swelling and Coalescence to Gel Layer FormationThis poster reprint investigates swelling and coalescence behaviour of hydroxypropylmethyl cellulose (HPMC) and partially pregelatinised starch particles, in order to monitor the contribution to gel layer formation in mixed HPMC and Starch 1500® matrices.
The Effect of Film Coating and Storage Conditions on the Performance of Metformin HCl 500 mg Extended Release Hypromellose MatricesThis poster reprint investigates the influence of three film coating systems on the performance of Metformin HCl (500mg) extended release (ER) Hypromellose matrices stored under different conditions up to 12 months.
The Effect of In-Vitro Dissolution Parameters on the Release Rate of a Low Dose, Low Solubility Drug from Extended Release Hypromellose Matrix Formulations This poster reprint examines the impact of dissolution testing parameters on a low dose, low solubility, METHOCEL™ matrix formulation, compared to a marketed reference product.
The Influence of Anionic Polymers on Hydrochlorothiazide Extended Release Hypromellose MatricesThis poster reprint summarizes the effect of blending anionic polymers (carbomer and polyvinyl acetate phthalate [PVAP, Phthalavin®]) with HPMC, on extending the release of a very slightly soluble drug (~1.0 mg/ml). The effects of varying the polymer blend ratio and excipient choice were studied in terms of drug release profile and textural properties of the hydrated matrix tablets.
The Influence of Film Coatings on Performance of Hypromellose MatricesPoster reprint which examines the influence of various immediate release film coatings on the drug release from METHOCEL™ matrices.
The Influence of Formulation Variables on Drug Release Kinetics from Hypromellose Extended Release MatricesThis poster reprint utilizes mathematical modeling to summarize the influence of several formulation variables on drug release from METHOCEL™ matrices.
The Influence of Hydro-Alcoholic Media on Hypromellose Matrix SystemsThis poster reprint investigates the effect of hydro-alcoholic dissolution media on the swelling and drug release properties of METHOCEL™ matrices.
The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240mg) Extended Release FormulationThis poster reprint examines the impact of the type of dissolution testing method on drug release from extended release verapamil hydrochloride METHOCEL™ matrices.
Use of Roller Compaction in the Preparation of Verapamil Hydrochloride Extended Release Matrix Tablets Containing Hydrophilic PolymersThe purpose of this study was to evaluate the effects of roller compaction on the flow and compressibility of blends of HPMC, polyvinyl acetate phthalate(PVAP) and carbomer [cross-linked poly (acrylicacid)]. Drug release of an ER verapamil HCl matrix formulation containing this blend was also evaluated.
Application of a Modeling System in the Formulation of Extended Release Hydrophilic MatricesThis article reprint describes a predictive formulation service that provides pharmaceutical scientists with a starting formula for hydrophilic matrix tablets.
Excipient Update, Influence of fillers, compression force, film coating, and storage conditions on Performance of Hypromellose matricesInvestigates the influence of fillers, compression force, film coating, and storage conditions on performance of hypromellose matrices.
The Influence of Excipients on Drug Release from Hydroxypropyl Methylcellulose MatricesPublished article reprint that summarizes the influence of various excipient fillers on the drug release from METHOCEL™ matrices.
