Surelease is a platform of complete, extended release, aqueous coating systems utilizing ethylcellulose as the rate controlling polymer for drug release. The dispersions are a unique combination of film-forming polymer, plasticizer and stabilizers; that can be used for modified release and taste masking applications. This advanced technology provides reliable and reproducible release profiles that are consistent from the laboratory, to pilot and production scale processes.
The primary means of drug release is by diffusion through the Surelease membrane and is directly controlled by film thickness. By simply increasing or decreasing the amount of Surelease applied, the rate of drug release is modified. No matter what quantity is used, Surelease dispersions consistently provide uniform drug release independent of pH.
The easy adjustment of release profiles provides significant time savings both in development and production. Furthermore, process optimization ensures the coating is fully coalesced, which completely eliminates the need for a curing step. Surelease has proven performance, as well as scalability since it provides consistent results beginning in the lab through to production. Surelease is also safe to use with components that meet the requirements of major pharmacopeia, and registered product approvals world wide.
