AFFINISOL™ Solubility Enhancing Polymers

Solving the Insoluble

AFFINISOL™ Hypromellose Acetate Succinate (HPMCAS) for Spray-Dried Dispersion (SDD) and AFFINISOL™ Hydroxypropyl Methylcellulose for Hot Melt Extrusion (HME)


Poor solubility of active pharmaceutical ingredients (API) is the leading challenge faced by the pharmaceutical industry. AFFINISOL™ polymers are uniquely tailored to address the solubilization requirement of these APIs.



AFFINISOL™ hypromellose acetate succinate (HPMCAS) is a soluble polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization. In addition, AFFINISOL™ HPMCAS can be customized with distinct acetate and succinate substitution levels to maximize the solubility enhancement and nucleation inhibition of your API.





AFFINISOL™ HPMC HME (hydroxypropyl methylcellulose) is designed for use in hot melt extrusion formulations, and used by pharmaceutical companies looking to enhance the solubilization and inhibit the recrystallization of APIs.

AFFINISOL™ is a trademark of The Dow Chemical Company