AFFINISOL™ Solubility Enhancing Polymers

Solving the Insoluble

AFFINISOL™ Hypromellose Acetate Succinate (HPMCAS) for Spray-Dried Dispersion (SDD) and AFFINISOL™ Hydroxypropyl Methylcellulose for Hot Melt Extrusion (HME)


Poor solubility of active pharmaceutical ingredients (API) is the leading challenge faced by the pharmaceutical industry. AFFINISOL™ polymers are uniquely tailored to address the solubilization requirement of these APIs.



AFFINISOL™ hypromellose acetate succinate (HPMCAS) is a soluble polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization. In addition, AFFINISOL™ HPMCAS can be customized with distinct acetate and succinate substitution levels to maximize the solubility enhancement and nucleation inhibition of your API.





AFFINISOL™ HPMC HME (hydroxypropyl methylcellulose) is designed for use in hot melt extrusion formulations, and used by pharmaceutical companies looking to enhance the solubilization and inhibit the recrystallization of APIs.

Product Literature

AFFINISOL™ is a trademark of The Dow Chemical Company