Over the last decade, there has been increasing interest in the development of oral osmotic devices in which the active pharmaceutical ingredient can be delivered in a sustained pattern over a long period of time governed by osmotic pressure.
Osmotic dosage forms provide zero order drug release that is generally independent of pH, ionic strength, agitation and other physiological factors within the gastrointestinal tract (GIT). These attributes minimize patient-to-patient variability and allow accurate prediction of in vivo performance from in vitro dissolution profiles.
Push-pull osmotic pump (PPOP) technology consists of a bilayer compressed tablet, with a pull layer, also referred to as drug layer, and a push layer. The core is coated with a semipermeable membrane (SPM) through which a drug delivery orifice is drilled using a laser drill.
The pull and push layers contain POLYOX™ Water-Soluble Resins which hydrate and swell, building osmotic pressure within the core and eventually leading to a constant release of drug through the orifice.
Opadry® CA ready formulated osmotic coating system, utilising cellulose acetate polymer, is applied as the SPM coating.
Colorcon now provides polymers and applications support to simplify formulation, scale-up and manufacture of osmotic tablets.
POLYOX™ is a trademark of The Dow Chemical Company