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RETURN TO MAIN PAGE  NEXT COATING ISSUE

 

Edge Chipping / Erosion

 
 

Possible Causes Solutions
  • Low mechanical strength of coating
    		•
  • Select OPADRY II formulation with improved mechanical strength
    		•
  • Excessive pan speed
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  • Decrease pan speed
    		•
  • Low solids content in coating liquid
    		•
  • Increase solids content of coating liquid
    		•
  • Low spray rate
    		•
  • Increase spray rate
    		•
  • Sharp edges on tablets
    		•
  • Replace or use modified punch design (use dual radius punch tips)
    		•
  • Worn tablet punches
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  • Refurbish or replace punches
    		•
  • Low tablet hardness / friability
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  • Improve mechanical strength of core by increasing compression force, changing tablet shape, modifying core formulation or hanging process by which core is produced (e.g. use granulation process instead of direct compression)
    		•
     
  • Change direct compression process to wet granulation
    		•