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RETURN TO MAIN PAGE  NEXT COATING ISSUE

 

Cracking

 

 

Possible Causes Solutions
  • Low mechanical strength of coating, exacerbated by inadequate plasticization or excessive pigmentation
    		•
  • Select OPADRY II formulation with improved mechanical strength and elasticity characteristics
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  • Core has significantly different thermal expansion characteristics than coating
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  • Avoid use of mineral-type fillers (e.g. calcium carbonate, calcium sulfate, magnesium carbonate) where possible
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  • Extended elastic recovery of core after compression
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  • Extend holding period for tablets prior to submitting them to coating process
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  • Inadequate plasticization
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  • Extend holding period for tablets prior to submitting them to coating process
    		•