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Core Erosion 

 

Possible Causes Solutions
  • Inherent softness or high friability of core
    		•
  • Improve mechanical strength of core by increasing compaction force, modifying core formulation or changing process by which core is produced (e.g. use granulation process instead of direct compression
    		•
  • Excessive pan speed in coating process
    		•
  • Reduce pan speed
    		•
  • Spray rate too low
    		•
  • Increase spray rate
    		•
  • Low solids content of spray solution
    		•
  • Select OPADRY II formulation with high solids content
    		•
  • Premature swelling of hydrophilic super disintegrant in formulation
    		•
  • Replace super disintegrant with less hydrophilic disintegrant like
    • STARCH 1500