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Zero Order Release
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The ability to deliver a drug at a rate which is independent of time and the concentration of drug within a pharmaceutical dosage form is desirable. Zero order mechanism ensures that a steady amount of drug is released over time, minimizing potential peak/trough fluctuations and side effects, while maximizing the amount of time the drug concentrations remain within the therapeutic window (efficacy). This is particularly important for 24 hour delivery of drugs with a narrow therapeutic index. Osmotic tablet formulations, coated tablet matrices, and the use of polymer combinations in hydrophilic matrices can be utilized to provide zero order drug release profiles.
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All trademarks, except where noted, are property of BPSI Holdings LLC.
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