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Modified Enteric Release

This is a variation on the traditional enteric drug release profile where enteric coating actually allows for a small portion of a drug dose to be released into the stomach, with the remainder of release occurring rapidly upon passage of the dosage form into the small intestine. This release profile is particularly suited to drugs which demonstrate site specific absorption in the upper portion of the GI tract (duodenum, jejunum), or where high dose drugs are being delivered which have narrow therapeutic indices. These high volume formulations can result in prolonged gastric retention times, which can then release drug close to the time when the next dose is delivered, thereby resulting in potential overdose of patients. Such a release profile can be achieved through the use of hydrophilic pore formers in pH dependent enteric coatings.