Multiparticulate Systems
In a multiparticulate drug delivery system, the dosage of the drug is divided among several discrete delivery entities, in contrast to a classical single-unit dosage form. Although multi-unit systems are more complicated to formulate and manufacture, they provide many advantages over single-unit modified release systems.
These systems are less dependent on gastric emptying rate, showing less subject variability in gastrointestinal transit time and dietary state. There is a lower tendency for local irritation as the drug is more widely distributed in the GI tract. In addition, because each unit functions as an individual modified release system, failure of a few units is less dangerous than the failure of a single-unit system, and reduces the possibility of dose dumping. The flexibility of programming defined position and release rates, into (potentially) each individual unit, provides considerable clinical advantages in delivering complex release profiles.
Colorcon’s product portfolio covers all aspects of multiparticulate development from a drug layering substrate to a final film coating;
