Extended release matrix systems contain a drug, one or more polymers, excipients; such as fillers or binders, a flow aid (glidant) and a lubricant. Depending on the choice of polymer, a formulator can design a hydrophilic, inert, or hydrophobic matrix. Other functional ingredients such as buffering agents, stabilizers, solubilizers, and surfactants, may also be included to improve or optimize the drug release or the stability of a dosage form.
Matrix technologies are utilized in greater than 75% of the extended release products on the market today and are applicable across a broad range of therapeutic indication categories. Matrix systems are popular because they are well understood and can be manufactured with conventional equipment and processes, and have broad regulatory acceptance. In addition, consistent control of drug release has been successfully demonstrated in marketed products containing high and low drug dose. Due to the array of polymers available for use in matrices, drug release can be fine tuned for drugs of low, medium, or high solubility. The HyperStart™, oral solid dose starting formulation service, can assist you in selecting the proper polymer for your desired release profile.
Colorcon’s product portfolio covers all aspects of matrix development including hydrophilic and inert matrix platforms, as well as functional and aesthetic film coatings.
METHOCEL Surelease Coatings
POLYOX ETHOCEL & ETHOCEL FP
Colorcon invites you to see how our product portfolio and services can assist in your matrix tablet formulation needs.
We also have extensive application data to help our customers achieve the desired release profile. Or, contact our team of experts, who are always available to offer formulation knowledge and technical support in all phases of your product development.
